ArticleJournal of virology2007
Probing the flavivirus membrane fusion mechanism by using monoclonal antibodies.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
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- Novel approaches for the rapid development of rationally designed arbovirus vaccines.One health (Amsterdam, Netherlands) · 2023Article
- A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice.PLoS pathogens · 2022Article
- Article
- Article
- A novel mechanism of antibody-mediated enhancement of flavivirus infection.PLoS pathogens · 2017Article
- Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity.Microbiology and molecular biology reviews : MMBR · 2016Review
- Formalin Inactivation of Japanese Encephalitis Virus Vaccine Alters the Antigenicity and Immunogenicity of a Neutralization Epitope in Envelope Protein Domain III.PLoS neglected tropical diseases · 2015Article
- A game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infection.Progress in molecular biology and translational science · 2015Review
- Hantavirus Gn and Gc envelope glycoproteins: key structural units for virus cell entry and virus assembly.Viruses · 2014Review
- Atomic-level functional model of dengue virus Envelope protein infectivity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The type-specific neutralizing antibody response elicited by a dengue vaccine candidate is focused on two amino acids of the envelope protein.PLoS pathogens · 2013Article
- Viral membrane fusion and nucleocapsid delivery into the cytoplasm are distinct events in some flaviviruses.PLoS pathogens · 2013Article
- A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virus.Journal of virology · 2012Article
- Hepatitis C virus induces CD81 and claudin-1 endocytosis.Journal of virology · 2012Article
- Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus.The EMBO journal · 2012Article
- The human antibody response to dengue virus infection.Viruses · 2011Review
- The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion.Journal of virology · 2011Article
- Review
- Dengue virus ensures its fusion in late endosomes using compartment-specific lipids.PLoS pathogens · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we investigated in a flavivirus model (tick-borne encephalitis virus) the mechanisms of fusion inhibition by monoclonal antibodies directed to the different domains of the fusion protein (E) and to different sites within each of the domains by using in vitro fusion assays. Our data indicate that, depending on the location of their binding sites, the monoclonal antibodies impaired early or late stages of the fusion process, by blocking the initial interaction with the target membrane or by interfering with the proper formation of the postfusion structure of E, respectively. These data provide new insights into the mechanisms of flavivirus fusion inhibition by antibodies and their possible contribution to virus neutralization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.