ArticleNucleic acids research2007
Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Emerging roles of FOXK2 in cancers and metabolic disorders.Frontiers in oncology · 2024Review
- Patterning the embryonic pulmonary mesenchyme.iScience · 2022Article
- Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors.eLife · 2022Article
- Genomic and Computational Analysis of Novel SNPs inGenetics research · 2022Article
- Revealing the Critical Regulators of Modulated Smooth Muscle Cells in Atherosclerosis in Mice.Frontiers in genetics · 2022Article
- ZbAGL11, a class D MADS-box transcription factor of Zanthoxylum bungeanum, is involved in sporophytic apomixis.Horticulture research · 2021Article
- Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos.microPublication biology · 2020Article
- FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function.Cell reports · 2020Article
- IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner.Nucleic acids research · 2019Article
- SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells.Oncogenesis · 2018Article
- Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors.Nucleic acids research · 2016Article
- JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.The Journal of biological chemistry · 2015Article
- The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression.mBio · 2015Article
- The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.Nucleic acids research · 2014Article
- The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells.The Journal of biological chemistry · 2013Article
- Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control.Molecular biology of the cell · 2012Article
- The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.Molecular and cellular biology · 2012Article
- Opposing oncogenic activities of small DNA tumor virus transforming proteins.Trends in microbiology · 2011Review
- Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes.The Journal of biological chemistry · 2010Article
- A competitive transcription factor binding mechanism determines the timing of late cell cycle-dependent gene expression.Molecular cell · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The combinatorial control of gene expression by the association of members of different families of transcription factors is a common theme in eukaryotic transcriptional control. The MADS-box transcription factors SRF and Mcm1 represent paradigms for such regulation through their interaction with numerous partner proteins. For example, in Saccharomyces cerevisiae, Mcm1 interacts with the forkhead transcription factor Fkh2. Here, we identify a novel interaction between SRF and the Forkhead transcription factor FOXK1 in human cells. The importance of this interaction is shown for the regulation of the SRF target genes SM alpha-actin and PPGB. The binding of FOXK1 to the SM alpha-actin and PPGB promoters requires the presence of SRF on the promoter. FOXK1 acts as a transcriptional repressor and it represses SM alpha-actin and PPGB expression. Thus FOXK1 represents an additional member of the growing repertoire of transcription factors that can interact with SRF and modulate the transcriptional output from SRF-regulated promoters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.