ArticleFertility and sterility2008
Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C).
Article in Fertility and sterility, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Toll-like Receptor Expression Patterns in the Female Reproductive Tract of Sheep.Animals : an open access journal from MDPI · 2025Article
- Ovarian sex steroid and epithelial control of immune responses in the uterus and oviduct: human and animal models†.Biology of reproduction · 2024Article
- Review
- Defensins: defenders of human reproductive health.Human reproduction update · 2023Review
- Innate Immune Response Against HIV-1.Advances in experimental medicine and biology · 2021Article
- Human Fallopian Tube Epithelial Cell Culture Model To Study Host Responses to Chlamydia trachomatis Infection.Infection and immunity · 2020Article
- Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells.Clinical and experimental reproductive medicine · 2018Article
- Poly (I:C) and LPS induce distinct immune responses by ovarian stromal fibroblasts.Journal of reproductive immunology · 2018Article
- Variable localization of Toll-like receptors in human fallopian tube epithelial cells.Clinical and experimental reproductive medicine · 2018Article
- The Effect of Estradiol and Progesterone on Toll Like Receptor Gene Expression in A Human Fallopian Tube Epithelial Cell Line.Cell journal · 2016Article
- The role of pattern recognition receptors in the innate recognition of Candida albicans.Virulence · 2015Review
- The role of sex hormones and the tissue environment in immune protection against HIV in the female reproductive tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Expression of Toll-like receptors 7-10 in human fallopian tubes.Iranian journal of reproductive medicine · 2014Article
- Mucosal immunity in the female genital tract, HIV/AIDS.BioMed research international · 2014Review
- Role of the innate immunity in female reproductive tract.Advanced biomedical research · 2014Review
- Article
- Pathogen recognition in the human female reproductive tract: expression of intracellular cytosolic sensors NOD1, NOD2, RIG-1, and MDA5 and response to HIV-1 and Neisseria gonorrhea.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Article
- Endocrine control of mucosal immunity in the female reproductive tract: impact of environmental disruptors.Molecular and cellular endocrinology · 2012Review
- Nuclear factor kappa B plays a pivotal role in polyinosinic-polycytidylic acid-induced expression of human β-defensin 2 in intestinal epithelial cells.Clinical and experimental immunology · 2011Article
- Importance of innate mucosal immunity and the promises it holds.International journal of general medicine · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the expression of toll-like receptors (TLR) by primary human Fallopian tube epithelial cells (FTEC) and to determine whether exposure to the TLR3 agonist poly(I:C) induces an antiviral response.
designTissue culture study.
settingUniversity medical center. PATIENT(S): Premenopausal women undergoing hysterectomy. INTERVENTION(S): Primary human FTEC were grown to confluence and high transepithelial resistance and treated with TLR agonists. Conditioned media was collected and RNA was extracted and analyzed for the expression of cytokines, chemokines, and antimicrobial genes. MAIN OUTCOME MEASURE(S): The RNA was analyzed by real-time polymerase chain reaction and protein levels were assessed by enzyme-linked immunosorbent assay. RESULT(S): The FTEC were demonstrated to express TLR1-9 but not 10. Treatment of FTEC with TLR3 agonist poly(I:C) resulted in increased expression of interleukin-8, tumor-necrosis factor alpha, human beta-defensin 2, interferon beta, and interferon stimulated genes myxovirus resistance gene 1, 2',5'-oligoadenylate synthetase, and protein kinase R. Additionally, FTEC exposed to poly(I:C) also resulted in the induction of TLR2, TLR3, and TLR7. CONCLUSION(S): Our results suggest that FTEC are sensitive to viral infection and/or exposure to viral double-stranded RNA and can respond by secreting proinflammatory cytokines that mediate the initiation of an inflammatory response as well as expressing genes that can directly inhibit viral replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.