ArticleExperimental neurology2007
Chondroitinase treatment increases the effective length of acellular nerve grafts.
Article in Experimental neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- The effectiveness of acellular nerve allografts compared to autografts in animal models: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Multichannel, biomimetic scaffolds improve functional connectivity following traumatic long-gap peripheral nerve injury.Nature communications · 2026Article
- Peripheral Nerve Decellularisation Protocol for Allogeneic Transplantation: From Tissue Procurement to Banking.International journal of molecular sciences · 2025Article
- Managing surface energy dynamics for enhanced axonal growth: An overview of present and future challenges.Biophysics reviews · 2025Review
- Development of Biomaterials for Addressing Upper Extremity Peripheral Nerve Gaps.Journal of hand surgery global online · 2024Review
- Histologic Comparison of the Fascicular Area of Processed Nerve Allograft Versus Cabled Sural Nerve Autograft.Plastic and reconstructive surgery. Global open · 2023Article
- Preparation and assessment of an optimized multichannel acellular nerve allograft for peripheral nerve regeneration.Bioengineering & translational medicine · 2023Article
- Evaluation of Processed Nerve Allograft in Peripheral Nerve Surgery: A Systematic Review and Critical Appraisal.Plastic and reconstructive surgery. Global open · 2023Article
- Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep.Cells · 2022Article
- Comparison of two different decellularization methods for processed nerve allograft.Cell and tissue banking · 2021Article
- Clinical Outcomes of Symptomatic Neuroma Resection and Reconstruction with Processed Nerve Allograft.Plastic and reconstructive surgery. Global open · 2021Article
- Reconstruction of Critical Nerve Defects Using Allogenic Nerve Tissue: A Review of Current Approaches.International journal of molecular sciences · 2021Review
- Decellularization of Nervous Tissues and Clinical Application.Advances in experimental medicine and biology · 2021Article
- Advances in the repair of segmental nerve injuries and trends in reconstruction.Muscle & nerve · 2020Review
- Decellularization techniques and their applications for the repair and regeneration of the nervous system.Methods (San Diego, Calif.) · 2020Review
- Glial Cell Line-Derived Neurotrophic Factor and Chondroitinase Promote Axonal Regeneration in a Chronic Denervation Animal Model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- Nerve grafting for peripheral nerve injuries with extended defect sizes.Wiener medizinische Wochenschrift (1946) · 2019Review
- Recovery of Motor Function after Mixed and Motor Nerve Repair with Processed Nerve Allograft.Plastic and reconstructive surgery. Global open · 2019Article
- Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits.Experimental and therapeutic medicine · 2018Article
- Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord.Biomedical materials (Bristol, England) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Acellular nerve allografts have been explored as an alternative to nerve autografting. It has long been recognized that there is a distinct limit to the effective length of conventional acellular nerve grafts, which must be overcome for many grafting applications. In rodent models nerve regeneration fails in acellular nerve grafts greater than 2 cm in length. In previous studies we found that nerve regeneration is markedly enhanced with acellular nerve grafts in which growth-inhibiting chondroitin sulfate proteoglycan was degraded by pretreatment with chondroitinase ABC (ChABC). Here, we tested if nerve regeneration can be achieved through 4-cm acellular nerve grafts pretreated with ChABC. Adult rats received bilateral sciatic nerve segmental resection and repair with a 4 cm, thermally acellularized, nerve graft treated with ChABC (ChABC graft) or vehicle-treated acellularized graft (Control graft). Nerve regeneration was examined 12 weeks after implantation. Our findings confirm that functional axonal regeneration fails in conventional long acellular grafts. In this condition we found very few axons in the distal host nerve, and there were marginal signs of sciatic nerve reinnervation in few (2/9) rats. This was accompanied by extensive structural disintegration of the distal graft and abundant retrograde axonal regeneration in the proximal nerve. In contrast, most (8/9) animals receiving nerve repair with ChABC grafts showed sciatic nerve reinnervation by direct nerve pinch testing. Histological examination revealed much better structural preservation and axonal growth throughout the ChABC grafts. Numerous axons were found in all but one (8/9) of the host distal nerves and many of these regenerated axons were myelinated. In addition, the amount of aberrant retrograde axonal growth (originating near the proximal suture line) was markedly reduced by repair with ChABC grafts. Based on these results we conclude that ChABC treatment substantially increases the effective length of acellular nerve grafts.
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Registered trials
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