ArticleJournal of the National Medical Association2007
Heat-shock protein gene is not associated with type-1 diabetes in African Americans.
Article in Journal of the National Medical Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The polymorphism at the heat-shock protein gene was reported to be associated with type-1 diabetes in Caucasians but not in the Japanese. We report in this study the association between HSP70-1 alleles and type-1 diabetes in 30 unrelated African-American patients and 96 ethnically matched controls from the Washington, DC area. The polymorphic variation (A-C transversion) at position -110 in the HSP70-1 promoter region was amplified using the polymerase chain reaction. No significant differences between patients and controls were detected. These data suggest that in African Americans, HSP70-1 polymorphism is not associated with type-1 diabetes and is similar to findings in Japanese patients. The difference between results from this study and that of Caucasians may be due to population differences in genetic polymorphism or to linkage disequilibrium of HSP70-1 with human leukocyte antigen class-II alleles associated with type-1 diabetes susceptibility genes.
Indexed as
Identifiers
17668636PMC2574349W53214485What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.