ArticleAmerican journal of human genetics2007
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 5 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome.Human reproduction (Oxford, England) · 2022Pooled it
- Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) Association in Russian Diabetes Mellitus 2 Type Cohort and Meta-Analysis.PloS one · 2015Pooled it
- Pooled it
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.Nature genetics · 2008Pooled it
- Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium.Human heredity · 2008Pooled it
- PCOS - the many faces of a disorder in women and men.Journal of endocrinological investigation · 2025Review
- Diabetes in China: epidemiology, pathophysiology and multi-omics.Nature metabolism · 2025 · on this mapReview
- Novel Risk Variants in the Oxytocin Receptor Gene (International journal of molecular sciences · 2023Article
- Variants ofJournal of the Endocrine Society · 2022Article
- Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?Marine drugs · 2021Review
- Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association-identified risk variants in a Southeastern Brazilian population.Clinical oral investigations · 2021Article
- The 'Jekyll and Hyde' of Gluconeogenesis: Early Life Adversity, Later Life Stress, and Metabolic Disturbances.International journal of molecular sciences · 2021Review
- The COVID-19 Pandemic: Does Our Early Life Environment, Life Trajectory and Socioeconomic Status Determine Disease Susceptibility and Severity?International journal of molecular sciences · 2020Review
- Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes inMolecular & cellular proteomics : MCP · 2020Article
- Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links.Frontiers in endocrinology · 2018Review
- PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies.Nature communications · 2017Article
- LncRNAs: key players and novel insights into diabetes mellitus.Oncotarget · 2017Review
- Association of polymorphic markers of genesPeerJ · 2017Article
- Utilization of genetic data can improve the prediction of type 2 diabetes incidence in a Swedish cohort.PloS one · 2017Article
- Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans.Journal of endocrinology and metabolism · 2015Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors.
Funding
Abstract
Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.