ArticleAmerican journal of human genetics2007
Case-control association testing with related individuals: a more powerful quasi-likelihood score test.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
116 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Case-control association mapping by proxy using family history of disease.Nature genetics · 2017Pooled it
- Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.Nature communications · 2015Pooled it
- Genome-wide interaction studies reveal sex-specific asthma risk alleles.Human molecular genetics · 2014Pooled it
- A genome-wide association study on African-ancestry populations for asthma.The Journal of allergy and clinical immunology · 2010Pooled it
- JASPER: Fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression.American journal of human genetics · 2024Article
- Article
- JASPER: fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression.bioRxiv : the preprint server for biology · 2023Article
- Exploiting family history in aggregation unit-based genetic association tests.European journal of human genetics : EJHG · 2022Article
- Incorporating family disease history and controlling case-control imbalance for population-based genetic association studies.Bioinformatics (Oxford, England) · 2022Article
- Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish.Investigative ophthalmology & visual science · 2022Article
- A generalized robust allele-based genetic association test.Biometrics · 2022Article
- Analysis of GWAS-nominated loci for lung cancer and COPD revealed a new asthma locus.BMC pulmonary medicine · 2022Article
- Family history aggregation unit-based tests to detect rare genetic variant associations with application to the Framingham Heart Study.American journal of human genetics · 2022Article
- Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family.Human genetics · 2021Article
- Multivariate linear mixed model enhanced the power of identifying genome-wide association to poplar tree heights in a randomized complete block design.G3 (Bethesda, Md.) · 2021Article
- Gene-Based Association Testing of Dichotomous Traits With Generalized Functional Linear Mixed Models Using Extended Pedigrees: Applications to Age-Related Macular Degeneration.Journal of the American Statistical Association · 2021Article
- An Efficient Score Test Integrated with Empirical Bayes for Genome-Wide Association Studies.Frontiers in genetics · 2021Article
- Variants of genes encoding TNF receptors and ligands and proteins regulating TNF activation in familial multiple sclerosis.CNS neuroscience & therapeutics · 2020Article
- Outcomes of 92 patient-driven family studies for reclassification of variants of uncertain significance.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Exonic variants of genes related to the vitamin D signaling pathway in the families of familial multiple sclerosis using whole-exome next generation sequencing.Brain and behavior · 2019Article
56 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
We consider the problem of genomewide association testing of a binary trait when some sampled individuals are related, with known relationships. This commonly arises when families sampled for a linkage study are included in an association study. Furthermore, power to detect association with complex traits can be increased when affected individuals with affected relatives are sampled, because they are more likely to carry disease alleles than are randomly sampled affected individuals. With related individuals, correlations among relatives must be taken into account, to ensure validity of the test, and consideration of these correlations can also improve power. We provide new insight into the use of pedigree-based weights to improve power, and we propose a novel test, the MQLS test, which, as we demonstrate, represents an overall, and in many cases, substantial, improvement in power over previous tests, while retaining a computational simplicity that makes it useful in genomewide association studies in arbitrary pedigrees. Other features of the MQLS are as follows: (1) it is applicable to completely general combinations of family and case-control designs, (2) it can incorporate both unaffected controls and controls of unknown phenotype into the same analysis, and (3) it can incorporate phenotype data about relatives with missing genotype data. The methods are applied to data from the Genetic Analysis Workshop 14 Collaborative Study of the Genetics of Alcoholism, where the MQLS detects genomewide significant association (after Bonferroni correction) with an alcoholism-related phenotype for four different single-nucleotide polymorphisms: tsc1177811 (P=5.9x10(-7)), tsc1750530 (P=4.0x10(-7)), tsc0046696 (P=4.7x10(-7)), and tsc0057290 (P=5.2x10(-7)) on chromosomes 1, 16, 18, and 18, respectively. Three of these four significant associations were not detected in previous studies analyzing these data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.