ReviewEuropean journal of pediatrics2008
What is new in pertussis?
Review in European journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Acellular vaccines for preventing whooping cough in children.The Cochrane database of systematic reviews · 2014Pooled it
- Immunogenicity and safety results from a randomized multicenter trial comparing a Tdap-IPV vaccine (REPEVAX®) and a tetanus monovalent vaccine in healthy adults: new considerations for the management of patients with tetanus-prone injuries.Human vaccines & immunotherapeutics · 2012Trial
- Risk factors and mortality in children with severe pertussis: the role of exchange transfusion in a PICU.Italian journal of pediatrics · 2025Article
- Seroepidemiology of pertussis in the east of China: Estimates of incidence of infection in adolescents and adults pre- and post-COVID-19.Frontiers in public health · 2022Article
- Clinical characteristics and molecular detection ofIranian journal of microbiology · 2021Article
- Recent increase in pertussis incidence in Korea: an age-period-cohort analysis.Epidemiology and health · 2021Article
- Bordetella pertussis in children hospitalized with a respiratory infection: clinical characteristics and pathogen detection in household contacts.BMC research notes · 2018Article
- Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation.Epidemiology and infection · 2018Article
- A high seroprevalence of antibodies to pertussis toxin among Japanese adults: Qualitative and quantitative analyses.PloS one · 2017Article
- Pertussis Reinfection in an Adult: A Cause of Persistent Cough Not to Be Ignored.Case reports in infectious diseases · 2017Article
- Epidemiology of pertussis in Denmark, 1995 to 2013.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2016Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Understanding Trends in Pertussis Incidence: An Agent-Based Model Approach.American journal of public health · 2015Article
- Bordetella pertussis naturally occurring isolates with altered lipooligosaccharide structure fail to fully mature human dendritic cells.Infection and immunity · 2015Article
- Characteristics of pertussis outbreaks in Catalonia, Spain, 1997 to 2010.Human vaccines & immunotherapeutics · 2015Article
- Immune responses to pertussis antigens in infants and toddlers after immunization with multicomponent acellular pertussis vaccine.Clinical and vaccine immunology : CVI · 2014Article
- The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients.Jundishapur journal of microbiology · 2014Article
- Serodiagnosis as adjunct assay for pertussis infection in São Paulo, Brazil.Clinical and vaccine immunology : CVI · 2014Article
- Perplexities of pertussis: recent global epidemiological trends and their potential causes.Epidemiology and infection · 2014Review
- Geographical differences in whooping cough in Catalonia, Spain, from 1990 to 2010.BMC public health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite high vaccination coverage, over the last fifteen years there has been a worldwide resurgence of B. pertussis infection. While classical pertussis in the prevaccine era was primarily a childhood disease, today with widespread vaccination, there has been a shift in the incidence of disease to adolescents and adults. Centers of Disease Control and Prevention (CDC) data from 2004 reveal a nearly 19-fold increase in the number of cases in individuals 10-19 years and a 16-fold increase in persons over 20 years. Indeed adolescent and adults play a significant role in the transmission of pertussis to neonates and infants who are vulnerable to substantial morbidity and mortality from pertussis infection. Several explanations have been proposed to explain the increasing incidence of disease, with waning immunity after natural infection or immunization being widely cited as a significant factor. Improving molecular biology diagnostic techniques, namely PCR assays, also accounts for the increasing laboratory diagnosis of pertussis. Expanding vaccination strategies including universal immunization of adolescents, targeted immunization of adults, and in particular, healthcare workers, childcare providers and parents of newborns, will likely improve pertussis control. With pertussis continuing to pose a serious threat to infants, and greatly affecting adolescents and adults, there remains a need to: (a) increase the awareness of physicians as to the growing pertussis problem, (b) standardize diagnostic techniques, and (c) implement various new vaccine strategies to enhance its control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.