ArticleIntensive care medicine2007
Ultrasonography of the optic nerve sheath may be useful for detecting raised intracranial pressure after severe brain injury.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 167 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Optic Nerve Sheath Diameter According to Position During Laparoscopy
Diagnostic Accuracy of Optic Nerve Ultrasound for the Detection of Intracranial Hypertension and Prediction of Therapeutic Intensity Level and Mortality Following Severe Traumatic Brain Injury (ONUS-TBI): a Prospective Blinded Study
Accuracy of Optic Nerve Sheath Diameter Measurement From Ultrasound Videos Using an Image Analysis Algorithm Compared to Expert Measurement in Patients With Acute Brain Injury
Efficacy of a Theoretical-practical Course for the Ultrasound Measurement of the Optic Nerve Diameter in Different Healthcare Operators
Who cites it
167 citing papers in PubMed, 7 syntheses or guidelines pooled it, 492 citations in OpenAlex.
- Sonographic optic nerve sheath diameter measurement for detecting intracranial hypertension in a suspected population: a systematic review and meta-analysis of diagnostic thresholds and influencing factors.Journal of neurology · 2026Pooled it
- B-mode transorbital ultrasonography for the diagnosis of idiopathic intracranial hypertension: an updated systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2019Pooled it
- Brain ultrasonography: methodology, basic and advanced principles and clinical applications. A narrative review.Intensive care medicine · 2019Pooled it
- Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: a systematic review and meta-analysis.Intensive care medicine · 2018Pooled it
- Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis.Intensive care medicine · 2011Pooled it
- Comparison of the Effects of Conventional and Piezoelectric Osteotomy on Intracranial Pressure Changes in Rhinoplasty Using Ultrasonographic Measurement of Optic Nerve Sheath Diameter.Aesthetic plastic surgery · 2026Trial
- Effects of Supraglottic Airway Devices on Hemodynamic Response and Optic Nerve Sheath Diameter: Proseal LMA, LMA Supreme, and I-gel LMA.Medicina (Kaunas, Lithuania) · 2023Trial
- Reverse Trendelenburg position applied prior to pneumoperitoneum prevents excessive increase in optic nerve sheath diameter in laparoscopic cholecystectomy: randomized controlled trial.Journal of clinical monitoring and computing · 2021Trial
- Does Tourniquet Time or Pressure Contribute to Intracranial Pressure Increase following Tourniquet Application?Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019Trial
- Correlation of optic nerve sheath diameter with directly measured intracranial pressure in Korean adults using bedside ultrasonography.PloS one · 2017Trial
- Optic nerve sonography in the diagnostic evaluation of adult brain injury.Critical care (London, England) · 2008Trial
- Optic Nerve Sheath Diameter and Transcranial Doppler Pulsatility Index for Non-Invasive ICP Assessment in Acute Intracerebral Hemorrhage.Brain sciences · 2026Article
- Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure and clinical severity in children: a prospective observational study.European journal of pediatrics · 2026Observational
- Observational
- Neurofilament light chain levels as a biomarker in idiopathic intracranial hypertension: correlations with papilledema and radiological findings.Acta neurologica Belgica · 2026Article
- Dose-dependent reduction of optic nerve sheath diameter during graded lower body negative pressure in healthy adults of both sexes.Frontiers in network physiology · 2026Article
- Ultrasonographic optic nerve sheath diameter as a non-invasive marker of intracranial hypertension in pediatric patients: a pilot study.Frontiers in pediatrics · 2026Article
- Point-of-care ultrasonography for detecting raised intracranial pressure through optic nerve sheath diameter in non-traumatic headache patients.World journal of radiology · 2025Review
107 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess at admission to the ICU the relationship between optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) and to investigate whether increased ONSD at patient admission is associated with raised ICP in the first 48[Symbol: see text]h after trauma. DESIGN AND
settingProspective, blind, observational study in a surgical critical care unit, level 1 trauma center. PATIENTS AND
participants31 adult patients with severe traumatic brain injury (TBI; Glasgow coma scale <or=8) requiring sedation and ICP monitoring, and 31 control patients without brain injury requiring sedation. MEASUREMENTS AND
resultsONSD was measured with a 7.5-MHz linear ultrasound probe. Two TBI groups were defined on the basis of ICP profile. If ICP exceeded 20 mmHg for more than 30 min in the first 48 h (before any specific treatment), patients were considered to have high ICP; if not, they had normal ICP. The largest ONSD value (the highest value for the right and left eye) was significantly higher in high ICP patients (6.3 +/-0.6 vs. 5.1+/-0.7 mm in normal ICP patients and 4.9+/-0.3mm in control patients). There was a significant relationship between the largest ONSD and ICP at admission (r=0.68). The largest ONSD was a suitable predictor of high ICP (area under ROC curve 0.96). When ONSD was under 5.7 mm, the sensitivity and negative predictive values for high ICP were 100%.
conclusionsIn the early posttraumatic period, ocular ultrasound scans may be useful for detecting high ICP after severe TBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.