ArticleEMBO reports2007
High-throughput mapping of origins of replication in human cells.
Article in EMBO reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 77 citations in OpenAlex.
- The Protective Role of Dormant Origins in Response to Replicative Stress.International journal of molecular sciences · 2018Review
- The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.The EMBO journal · 2018Article
- A journey through the microscopic ages of DNA replication.Protoplasma · 2017Review
- FANCD2 Facilitates Replication through Common Fragile Sites.Molecular cell · 2016Article
- De novo identification of replication-timing domains in the human genome by deep learning.Bioinformatics (Oxford, England) · 2016Article
- Peaks cloaked in the mist: the landscape of mammalian replication origins.The Journal of cell biology · 2015Review
- The hunt for origins of DNA replication in multicellular eukaryotes.F1000prime reports · 2015Review
- The role of transcription in the activation of a Drosophila amplification origin.G3 (Bethesda, Md.) · 2014Article
- Targeted tandem duplication of a large chromosomal segment in Aspergillus oryzae.Applied and environmental microbiology · 2014Article
- The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells.PLoS genetics · 2014Article
- Human genome replication proceeds through four chromatin states.PLoS computational biology · 2013Article
- Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm.Nature protocols · 2013Article
- Replication origins run (ultra) deep.Nature structural & molecular biology · 2012Article
- Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs.Nature structural & molecular biology · 2012Article
- Measures of compositional strand bias related to replication machinery and its applications.Current genomics · 2012Article
- Initiation of DNA Replication in the Human Genome.Hereditary genetics : current research · 2012Article
- Article
- Developmental control of gene copy number by repression of replication initiation and fork progression.Genome research · 2012Article
- Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.The Journal of biological chemistry · 2011Article
- Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Mapping origins of replication has been challenging in higher eukaryotes. We have developed a rapid, genome-wide method to map origins of replication in asynchronous human cells by combining the nascent strand abundance assay with a highly tiled microarray platform, and we validated the technique by two independent assays. We applied this method to analyse the enrichment of nascent DNA in three 50-kb regions containing known origins of replication in the MYC, lamin B2 (LMNB2) and haemoglobin beta (HBB) genes, a 200-kb region containing the rare fragile site, FRAXA, and a 1,075-kb region on chromosome 22; we detected most of the known origins and also 28 new origins. Surprisingly, the 28 new origins were small in size and located predominantly within genes. Our study also showed a strong correlation between origin replication timing and chromatin acetylation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.