ArticleMolecular psychiatry2008
A whole genome association study of neuroticism using DNA pooling.
Article in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism.Journal of human genetics · 2017Pooled it
- GWA meta-analysis of personality in Korean cohorts.Journal of human genetics · 2015Pooled it
- Meta-analysis of genome-wide association studies for personality.Molecular psychiatry · 2012Pooled it
- Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.Translational psychiatry · 2011Pooled it
- Genome-wide association scan of trait depression.Biological psychiatry · 2010Pooled it
- Recursive splicing is a rare event in the mouse brain.PloS one · 2022Article
- Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population.Molecular psychiatry · 2021Article
- Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits.Frontiers in neuroanatomy · 2020Article
- The genetics of human personality.Genes, brain, and behavior · 2018Review
- GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.Molecular psychiatry · 2017Article
- Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.Behavior genetics · 2014Article
- The genetics of major depression.Neuron · 2014Review
- Heritability and linkage analysis of personality in bipolar disorder.Journal of affective disorders · 2013Article
- Neuroticism and common mental disorders: meaning and utility of a complex relationship.Clinical psychology review · 2013Review
- TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample.Journal of molecular neuroscience : MN · 2013Article
- Anxiety genetics - findings from cross-species genome-wide approaches.Biology of mood & anxiety disorders · 2013Article
- Cost-effective genome-wide estimation of allele frequencies from pooled DNA in Atlantic salmon (Salmo salar L.).BMC genomics · 2013Article
- The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders.Frontiers in pharmacology · 2013Article
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17 authors at 6 institutions in 4 countries.
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Abstract
We describe a multistage approach to identify single nucleotide polymorphisms (SNPs) associated with neuroticism, a personality trait that shares genetic determinants with major depression and anxiety disorders. Whole genome association with 452 574 SNPs was performed on DNA pools from approximately 2000 individuals selected on extremes of neuroticism scores from a cohort of 88 142 people from southwest England. The most significant SNPs were then genotyped on independent samples to replicate findings. We were able to replicate association of one SNP within the PDE4D gene in a second sample collected by our laboratory and in a family-based test in an independent sample; however, the SNP was not significantly associated with neuroticism in two other independent samples. We also observed an enrichment of low P-values in known regions of copy number variations. Simulation indicates that our study had approximately 80% power to identify neuroticism loci in the genome with odds ratio (OR)>2, and approximately 50% power to identify small effects (OR=1.5). Since we failed to find any loci accounting for more than 1% of the variance, the heritability of neuroticism probably arises from many loci each explaining much less than 1%. Our findings argue the need for much larger samples than anticipated in genetic association studies and that the biological basis of emotional disorders is extremely complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.