ArticleMolecular psychiatry2007
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 6 of them syntheses that pooled it.
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131 citing papers in PubMed, 6 syntheses or guidelines pooled it, 358 citations in OpenAlex.
- DNA methylation in peripheral tissues and left-handedness.Scientific reports · 2022Pooled it
- Genome-wide association study identifies 48 common genetic variants associated with handedness.Nature human behaviour · 2021Pooled it
- Pooled it
- Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.PLoS genetics · 2013Pooled it
- Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.Translational psychiatry · 2011Pooled it
- Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.Proceedings of the National Academy of Sciences of the United States of America · 2009Pooled it
- Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and alleles.bioRxiv : the preprint server for biology · 2026Article
- A decade of progress in understanding LRRTM and Slitrk synaptic cell-adhesion molecules.Molecules and cells · 2026Review
- Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.World journal of psychiatry · 2026Review
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- A comprehensive analysis of allele-specific expression and transcriptomic profiling in pig limbic and endocrine tissues.Frontiers in molecular neuroscience · 2025Article
- Methylome profile of medaka eggs and sperm.Epigenetics · 2024Article
- Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity.Molecular neurobiology · 2024Article
- Divergent epigenetic responses to perinatal asphyxia in severe mental disorders.Translational psychiatry · 2024Article
- Relationships of lower extremity and trunk asymmetries in elite soccer players.Frontiers in physiology · 2024Article
- Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.medRxiv : the preprint server for health sciences · 2023Article
- Genomic analysis of firework fear and noise reactivity in standard poodles.Canine medicine and genetics · 2023Article
- Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.Nature communications · 2023Article
- Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.eLife · 2022Article
71 more citing papers are in PubMed but not listed here.
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42 authors at 18 institutions in 11 countries.
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Abstract
Left-right asymmetrical brain function underlies much of human cognition, behavior and emotion. Abnormalities of cerebral asymmetry are associated with schizophrenia and other neuropsychiatric disorders. The molecular, developmental and evolutionary origins of human brain asymmetry are unknown. We found significant association of a haplotype upstream of the gene LRRTM1 (Leucine-rich repeat transmembrane neuronal 1) with a quantitative measure of human handedness in a set of dyslexic siblings, when the haplotype was inherited paternally (P=0.00002). While we were unable to find this effect in an epidemiological set of twin-based sibships, we did find that the same haplotype is overtransmitted paternally to individuals with schizophrenia/schizoaffective disorder in a study of 1002 affected families (P=0.0014). We then found direct confirmatory evidence that LRRTM1 is an imprinted gene in humans that shows a variable pattern of maternal downregulation. We also showed that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity. This is the first potential genetic influence on human handedness to be identified, and the first putative genetic effect on variability in human brain asymmetry. LRRTM1 is a candidate gene for involvement in several common neurodevelopmental disorders, and may have played a role in human cognitive and behavioral evolution.
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