ArticleMolecular psychiatry2008
Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder.
Article in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 194 citations in OpenAlex.
- Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of (1) H-MRS studies.Human brain mapping · 2016Pooled it
- Effects of yoga versus walking on mood, anxiety, and brain GABA levels: a randomized controlled MRS study.Journal of alternative and complementary medicine (New York, N.Y.) · 2010Trial
- Anesthetics as emerging therapeutics for post-traumatic stress disorder (PTSD): bridging bench and bedside.Molecular psychiatry · 2026Review
- Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation.Molecular psychiatry · 2026Review
- Stellate Ganglion Block for Post-traumatic Stress Disorder: A Comprehensive Review of Evidence, Technique Considerations and Symptom Outcomes in Military and Non-Military Patients.Current psychiatry reports · 2026Review
- Unraveling Complex Interactions Mechanisms Linking PTSD and Chronic Diseases.Current neuropharmacology · 2026Review
- From Bench to Bedside: Understanding General Anesthetics' Impact on PTSD.Current neuropharmacology · 2026Review
- Precision phenotyping of elevated arousal in posttraumatic stress disorder: implications for personalized GABAergic pharmacotherapy.Frontiers in psychiatry · 2026Review
- Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder.Signal transduction and targeted therapy · 2025Article
- Radionuclide Imaging of Heart-Brain Connections.Heart failure clinics · 2025Review
- Neuroactive steroids and the pathophysiology of PTSD: Biomarkers for treatment targeting.Neuroscience and biobehavioral reviews · 2025Review
- A Comparison of the Effect of Two Doses of Oral Melatonin as Premedication on Orientation Score, Induction Compliance, and Emergency Agitation of Children Undergoing Elective Surgeries: A Double-Blinded Randomized Trial.Anesthesiology research and practice · 2025Article
- Review
- Identification of potential biomarkers and therapeutic targets related to post-traumatic stress disorder due to traumatic brain injury.European journal of medical research · 2024Article
- Radionuclide Imaging of Heart-Brain Connections.Cardiology clinics · 2023Review
- To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers.International journal of molecular sciences · 2023Review
- Influence of mental health medication on microbiota in the elderly population in the Valencian region.Frontiers in microbiology · 2023Article
- Characterization of gut microbiota profile in Iranian patients with bipolar disorder compared to healthy controls.Frontiers in cellular and infection microbiology · 2023Article
- Involvement of the GABAergic system in PTSD and its therapeutic significance.Frontiers in molecular neuroscience · 2023Review
- Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.Nature neuroscience · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma-aminobutyric acid (GABA(A)) receptors are thought to play an important role in modulating the central nervous system in response to stress. Animal data have shown alterations in the GABA(A) receptor complex by uncontrollable stressors. SPECT imaging with benzodiazepine ligands showed lower distribution volumes of the benzodiazepine-GABA(A) receptor in the prefrontal cortex of patients with post-traumatic stress disorder (PTSD) in one, but not in another study. The objective of the present study was to assess differences in the benzodiazepine-GABA(A) receptor complex in veterans with and without PTSD using [(11)C]flumazenil and positron emission tomography (PET). Nine drug naive male Dutch veterans with deployment related PTSD and seven male Dutch veterans without PTSD were recruited, and matched for age, region and year of deployment. Each subject received a [(11)C]flumazenil PET scan and a structural magnetic resonance imaging scan. Dynamic 3D PET scans with a total duration of 60 min were acquired, and binding in template based and manually defined regions of interest (ROI) was quantified using validated plasma input and reference tissue models. In addition, parametric binding potential images were compared on a voxel-by-voxel basis using statistical parametric mapping (SPM2). ROI analyses using both template based and manual ROIs showed significantly reduced [(11)C]flumazenil binding in PTSD subjects throughout the cortex, hippocampus and thalamus. SPM analysis confirmed these results. The observed global reduction of [(11)C]flumazenil binding in patients with PTSD provides circumstantial evidence for the role of the benzodiazepine-GABA(A) receptor in the pathophysiology of PTSD and is consistent with previous animal research and clinical psychopharmacological studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.