ArticleMolecular systems biology2007
Increased glycolytic flux as an outcome of whole-genome duplication in yeast.
Article in Molecular systems biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 126 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
126 citing papers in PubMed, 231 citations in OpenAlex.
- Article
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- Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes.The EMBO journal · 2026Article
- Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution.Nature ecology & evolution · 2026Article
- Nonredundant roles for paralogous proteins in the yeast glucose-sensing pathway.Molecular biology of the cell · 2026Article
- From one genome to thousands, and beyond.FEMS yeast research · 2026Review
- Non-redundant roles for paralogous proteins in the yeast glucose-sensing pathway.bioRxiv : the preprint server for biology · 2025Article
- Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes.bioRxiv : the preprint server for biology · 2025Article
- Discovery of additional ancient genome duplications in yeasts.bioRxiv : the preprint server for biology · 2025Article
- Fermentative factors shape transcriptional response of Lachancea thermotolerans and wine acidification.NPJ science of food · 2025Article
- Wine Fermentation as a Model System for Microbial Ecology and Evolution.Environmental microbiology · 2025Review
- Unveiling the thermotolerance mechanism of Pichia kudriavzevii LC375240 through transcriptomic and genetic analyses.BMC biology · 2025Article
- Chromosome-level subgenome-aware de novo assembly provides insight intoGenome research · 2024Article
- Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes.Molecular systems biology · 2024Article
- Chromosome-level Subgenome-awarebioRxiv : the preprint server for biology · 2024Article
- Comparing Mitochondrial Activity, Oxidative Stress Tolerance, and Longevity of ThirteenAntioxidants (Basel, Switzerland) · 2023Article
- Optimizing growth and biomass production of non-Frontiers in microbiology · 2023Article
- Genome sequencing ofFrontiers in plant science · 2023Article
- TheFEMS microbes · 2023Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After whole-genome duplication (WGD), deletions return most loci to single copy. However, duplicate loci may survive through selection for increased dosage. Here, we show how the WGD increased copy number of some glycolytic genes could have conferred an almost immediate selective advantage to an ancestor of Saccharomyces cerevisiae, providing a rationale for the success of the WGD. We propose that the loss of other redundant genes throughout the genome resulted in incremental dosage increases for the surviving duplicated glycolytic genes. This increase gave post-WGD yeasts a growth advantage through rapid glucose fermentation; one of this lineage's many adaptations to glucose-rich environments. Our hypothesis is supported by data from enzyme kinetics and comparative genomics. Because changes in gene dosage follow directly from post-WGD deletions, dosage selection can confer an almost instantaneous benefit after WGD, unlike neofunctionalization or subfunctionalization, which require specific mutations. We also show theoretically that increased fermentative capacity is of greatest advantage when glucose resources are both large and dense, an observation potentially related to the appearance of angiosperms around the time of WGD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.