ReviewMolecular endocrinology (Baltimore, Md.)2008
SRY and the standoff in sex determination.
Review in Molecular endocrinology (Baltimore, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 147 citations in OpenAlex.
- Navigating the Semantic Labyrinth of "Sex" in the Study of Reproductive Trait Evolution.Integrative and comparative biology · 2026Article
- Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep.Molecular and cellular endocrinology · 2024Article
- Analysis of a Yp11.2 region deletion in a Chinese female with Turner syndrome: A case report.Heliyon · 2023Article
- Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions.Frontiers in endocrinology · 2023Review
- SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation.Molecular neurobiology · 2021Review
- Doublesex controls specification and maintenance of the gonad stem cell niches inDevelopment (Cambridge, England) · 2019Article
- Translating genomics to the clinical diagnosis of disorders/differences of sex development.Current topics in developmental biology · 2019Review
- Advanced immunostaining approaches to study early male germ cell development.Stem cell research · 2018Article
- Dmrt1 is required for primary male sexual differentiation in Chinese soft-shelled turtle Pelodiscus sinensis.Scientific reports · 2017Article
- Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.Scientific reports · 2017Article
- Proper diagnosis and management of nonobstructive azoospermia: NYU Case of the Month, June 2017.Reviews in urology · 2017Article
- Polygenic sex determination in the cichlid fish Astatotilapia burtoni.BMC genomics · 2016Article
- Review
- Autosomal gsdf acts as a male sex initiator in the fish medaka.Scientific reports · 2016Article
- Physiologic Course of Female Reproductive Function: A Molecular Look into the Prologue of Life.Journal of pregnancy · 2015Review
- SOX7: from a developmental regulator to an emerging tumor suppressor.Histology and histopathology · 2014Review
- Environmental epigenetics and effects on male fertility.Advances in experimental medicine and biology · 2014Review
- Proteome differences between male and female fetal cells in amniotic fluid.Omics : a journal of integrative biology · 2013Article
- Gender dysphoria associated with disorders of sex development.Nature reviews. Urology · 2012Review
- What a difference an X or Y makes: sex chromosomes, gene dose, and epigenetics in sexual differentiation.Handbook of experimental pharmacology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
SRY was identified as the mammalian sex-determining gene more than 15 yr ago and has been extensively studied since. Although many of the pathways regulating sexual differentiation have been elucidated, direct downstream targets of SRY are still unclear, making a top down approach difficult. However, recent work has demonstrated that the fate of the gonad is actively contested by both male-promoting and female-promoting signals. Sox9 and Fgf9 push gonads towards testis differentiation. These two genes are opposed by Wnt4, and possibly RSPO1, which push gonads toward ovary differentiation. In this review, we will discuss the history of the field, current findings, and exciting new directions in vertebrate sex determination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.