Evidence map›Paper›PMID 17666449›Full record

ArticleAnnals of the rheumatic diseases2008

Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women.

K H Costenbader, D Feskanich, M Holmes, E W Karlson, E Benito-Garcia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 7 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 7 syntheses or guidelines pooled it, 214 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Role of vitamin D in flare ups of rheumatoid arthritis.Zeitschrift fur Rheumatologie · 2014
    Trial
  9. Trial
  10. Trial
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.Rheumatic diseases clinics of North America · 2022
    Review
  18. Article
  19. Review
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

K H CostenbaderDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. KCostenbader@partners.org
D Feskanich
M Holmes
E W Karlson
E Benito-Garcia
Brigham and Women's Hospital · USHarvard University · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIOVANNUCCI, EDWARD · 2000 to 2019
$77.8M
Trial of risk mangement for prevention of accelerated atherosclerosis in SLEP60AR047782 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2001 to 2016
$18.8M
Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
Novel Biomarkers and Prediction Models for Rheumatoid ArthritisR01AR049880 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COSTENBADER, KAREN H, KARLSON, ELIZABETH W · 2003 to 2018
$8.7M
Genetic Predictors of Early Atherosclerosis in SLEK24AR052403 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KARLSON, ELIZABETH W · 2005 to 2014
$1.5M
EFFECTS OF SILICONE ON THE IMMUNE RESPONSER01AR042630 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHUR, PETER H · 1993 to 1995
–
NCI NIH HHS CA87969NCI NIH HHS P01 CA087969NIAMS NIH HHS AR42630NIAMS NIH HHS K24 AR0524-01NIAMS NIH HHS K24 AR052403NIAMS NIH HHS P60 AR047782NIAMS NIH HHS R01 AR049880NIAMS NIH HHS R01 AR49880NICHD NIH HHS K12 HD051959
6 · The paper itself

Abstract

objectivesVitamin D has immune-modulating effects and may protect against the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

methodsWe identified incident cases of SLE and RA among 186 389 women followed from 1980 to 2002 in the Nurses' Health Study and Nurses' Health Study II cohorts. We excluded subjects where SLE or RA was not confirmed by medical record review, and those who failed to return questionnaires. Semi-quantitative food frequency questionnaires assessed vitamin D intake from food and supplements. We used cumulative-updated total energy-adjusted dietary exposures for each 2-year cycle. Relationships between vitamin D intake and incident SLE and RA were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results were pooled using meta-analysis random effects models.

resultsWe confirmed 190 incident cases of SLE and 722 of RA with dietary information. Increasing levels of vitamin D intake had no relationship to the relative risk of developing either SLE or RA.

conclusionsVitamin D intake was not associated with risk of SLE or RA in these large prospective cohorts of women.

Indexed as

AdultArthritis, RheumatoidEpidemiologic MethodsFeeding BehaviorFemaleHumansLife StyleLupus Erythematosus, SystemicMiddle AgedNutritional StatusUnited StatesVitamin DVitamin D

Identifiers

PMID17666449
PMCPMC2717608
OpenAlexW2153956738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.