Evidence map›Paper›PMID 17665514›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2006

Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.

Steve E Humphries, David Gable, Jackie A Cooper, Helen Ireland, Jeffrey W Stephens, Steven J Hurel, Ka Wah Li, Jutta Palmen, Michelle A Miller, Francesco P Cappuccio and 4 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 7 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 7 syntheses or guidelines pooled it, 167 citations in OpenAlex.

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  4. Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Steve E HumphriesDepartment of Medicine, Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, WC1E 6JF, UK. rmhaseh@ucl.ac.uk
David Gable
Jackie A Cooper
Helen Ireland
Jeffrey W Stephens
Steven J Hurel
Ka Wah Li
Jutta Palmen
Michelle A Miller
Francesco P Cappuccio
Robert Elkeles
Ian Godsland
George J Miller
Philippa J Talmud
British Heart Foundation · GBUniversity College London · GBSt Mary's Hospital · GBUniversity of Warwick · GBMedical Research Council · GBSwansea University · GB

Funding

PHS HHS NHLBI 33014
6 · The paper itself

Abstract

Common variants of TCF7L2, encoding a beta-cell-expressed transcription factor, are strongly associated with increased risk of type 2 diabetes (T2D). We examined this association using both prospective and case-control designs. A total of 2,676 healthy European white middle-aged men from the prospective NPHSII (158 developed T2D over 15 years surveillance) were genotyped for two intronic SNPs [rs 7903146 (IVS3C>T) and rs12255372 (IVS4G>T)] which showed strong linkage disequilibrium (D' = 0.88, p<0.001; R(2)=0.76, p<0.001). The IVS5T allele frequency was 0.28 (95% CI 0.27-0.29) and 0.33 (0.28-0.39) in healthy and T2D, respectively (p=0.04). Compared to CC men, CT and TT men had an adjusted [for age, body mass index, systolic blood pressure, triglyceride and C-reactive protein levels] hazard ratio for T2D of 1.65 (1.13-2.41) and 1.87 (0.99-3.53), respectively, p<0.01. The population attributable fraction for diabetes risk was 17%. In 1459, European white T2D men and women (60% male), T allele frequency was 0.36 (0.34-0.38), and compared to NPHSII healthy men the OR for T2D for the CT and TT subjects was 1.43 (1.24-1.65) and 2.11 (1.69-2.63), respectively p=<0.0001. A similar effect was observed in 919 T2D Indian Asians [OR=1.50 (1.14-1.99) and 1.64 (1.03-2.63) p=0.003] and 385 Afro-Caribbean subjects [OR=1.25 (0.90-1.75) and 1.32 (0.74-2.33) p=0.17] compared to non-diabetic ethnically matched subjects from South London. Weaker associations were found for the IVS4G>T in all studies. Linkage disequilibrium between the two SNPs was high in Indian Asians (D'=0.94), but much weaker in Afro-Caribbeans (D'=0.17) and haplotype frequencies differed markedly in this group. These results extend previous observations to other ethnic groups, and strongly confirm that TCF7L2 genotype is a major risk factor for development of T2D.

Indexed as

Genetic Predisposition to DiseaseGenetic VariationAllelesAsian PeopleBlack PeopleCase-Control StudiesDiabetes Mellitus, Type 2FemaleGene FrequencyHaplotypesHumansLinkage DisequilibriumMalePolymorphism, Single NucleotideProspective StudiesRacial GroupsTCF7L2 protein, humanTCF Transcription FactorsTranscription Factor 7-Like 2 Protein

Identifiers

PMID17665514
OpenAlexW2170087801

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.