Evidence map›Paper›PMID 17665457›Full record

ArticleArthritis and rheumatism2007

Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus.

Brent W Kinder, Michelle M Freemer, Talmadge E King, Raymond F Lum, Joanne Nititham, Kim Taylor, Jeffrey C Edberg, S Louis Bridges, Lindsey A Criswell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis and rheumatism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Altered peripheral lymphocyte subsets in untreated systemic lupus erythematosus patients with infections.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Brent W KinderDivision of Rheumatology, University of California-San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA.
Michelle M Freemer
Talmadge E King
Raymond F Lum
Joanne Nititham
Kim Taylor
Jeffrey C Edberg
S Louis Bridges
Lindsey A Criswell
University of California, San Francisco · USUniversity of Alabama at Birmingham · US

Funding

ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
Program Project in the Genetics of SLEP01AR049084 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2002 to 2012
$12.7M
The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZ, PATRICIA P · 2006 to 2016
$11.8M
TESTING SLE CANDIDATE LOCI USING CASES AND THEIR PARENTSR01AR044804 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CRISWELL, LINDSEY ANN · 1999 to 2003
$1.1M
The Genetic Epidemiology of RA and SLEK24AR002175 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CRISWELL, LINDSEY ANN · 2001 to 2005
$555k
NCRR NIH HHS 5M01 RR 00079NCRR NIH HHS M01 RR000032NCRR NIH HHS M01 RR000079NCRR NIH HHS M01 RR 00032NIAMS NIH HHS K24 AR002175NIAMS NIH HHS K24 AR 02175NIAMS NIH HHS P01 AR049084NIAMS NIH HHS P01 AR 49084NIAMS NIH HHS P60 AR053308NIAMS NIH HHS R01 AR 44804
6 · The paper itself

Abstract

objectiveTo define the contribution of polymorphisms in genes encoding tumor necrosis factor (TNF), mannose-binding lectin (MBL), and Fcgamma receptor IIa (FCGR2A) as well as clinical factors, to the development of pneumonia in patients with systemic lupus erythematosus (SLE).

methodsWe studied 282 SLE patients from a multiethnic cohort. Pneumonia events and clinical risk factors for pneumonia were identified through medical record review. Genotyping was performed for MBL (+223, +230, and +239), TNF (-308, -238, and +488), and FCGR2A (-131H/R) polymorphisms. Univariate analyses were performed to identify clinical and genetic risk factors for pneumonia. Covariates for multivariate analysis included sex, ethnicity, treatment with immunomodulators, and leukopenia.

resultsForty-two patients (15%) had at least 1 episode of pneumonia. Polymorphism of the TNF gene, particularly the -238A allele and a related haplotype, revealed the most striking and consistent association with pneumonia in univariate analyses. Results of multivariate analyses indicated an odds ratio (OR) for the TNF -238A allele of 3.5 (P = 0.007) and an OR for the related haplotype of 5.4 (P = 0.001). Male sex, treatment with immunomodulators, and leukopenia also influenced the risk of pneumonia.

conclusionThese findings suggest that specific TNF variants may identify SLE patients who are at particularly high risk of developing pneumonia. Given the prevalence and excessive morbidity associated with pneumonia in SLE, these findings have clinical relevance and provide insight into the pathogenesis.

Indexed as

Genetic Predisposition to DiseaseAdolescentAdultAgedAged, 80 and overCaliforniaChildChild, PreschoolCohort StudiesComorbidityEthnicityFemaleGenotypeHumansLupus Erythematosus, SystemicMaleFCGR2A protein, humanMannose-Binding LectinReceptors, IgGTumor Necrosis Factor-alpha

Identifiers

PMID17665457
PMCPMC2875177
OpenAlexW2109299306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.