ArticleThe Journal of membrane biology2007
Gap junction and purinergic P2 receptor proteins as a functional unit: insights from transcriptomics.
Article in The Journal of membrane biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
- Protein⁻Protein Interactions with Connexin 43: Regulation and Function.International journal of molecular sciences · 2018Review
- ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms.Scientific reports · 2018Article
- Gap junction modulation and its implications for heart function.Frontiers in physiology · 2014Review
- Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells.Frontiers in cellular neuroscience · 2014Article
- The connexin43-dependent transcriptome during brain development: importance of genetic background.Brain research · 2012Article
- Connexins and the kidney.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Review
- ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle.The Journal of biological chemistry · 2009Article
- Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention?Pediatric research · 2009Review
- Characterization of Calcium-Mediated Intracellular and Intercellular Signaling in the rMC-1 Glial Cell Line.Cellular and molecular bioengineering · 2009Article
- Dynamic ATP signalling and neural development.The Journal of physiology · 2008Review
- Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes.Cell communication & adhesion · 2008Article
- Article
- Organizational principles of the connexin-related brain transcriptome.The Journal of membrane biology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Gap junctions and purinergic P2 receptors (P2Rs) can be regarded as belonging to a common functional unit, given that they are involved in the transmission of calcium signals between cells. We have previously shown that deletion of the Gja1 gene alters expression levels of numerous genes encoding proteins with diverse functions, including purinergic receptors (P2Rs), and have found that genes synergistically or antagonistically expressed in wild-type tissues are more prone to be similarly or oppositely regulated in Cx43-nulls. We have now explored the use of coordination analysis of gene expression as a strategy to identify interlinked genes encoding functionally related proteins and pull-downs to evaluate their interlinkage. Our findings indicate that, in brain and in cultured astrocytes, several of these coexpressed genes encode proteins that are components of P2R signal-transduction pathways and/or directly interact with these receptors, including the gap junction protein connexin43 (Cx43) and Cx45 as well as pannexins. It is proposed that coordination analysis of gene expression may provide a novel unbiased strategy for the identification of proteins belonging to supramolecular complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.