ArticleThe Journal of general physiology2007
Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells.
Article in The Journal of general physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- The TRP channels serving as chemical-to-electrical signal converter.Physiological reviews · 2025Review
- Early heart development: examining the dynamics of function-form emergence.Biochemical Society transactions · 2024Review
- Epigenetic Regulation of Mammalian Cardiomyocyte Development.Epigenomes · 2024Review
- Review
- Inositol 1,4,5-trisphosphate receptors in cardiomyocyte physiology and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- The sodium channel NaActa physiologica (Oxford, England) · 2020Article
- Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells.PLoS computational biology · 2020Article
- CaCell calcium · 2020Review
- The First Heartbeat-Origin of Cardiac Contractile Activity.Cold Spring Harbor perspectives in biology · 2020Review
- Calcium Signaling in Cardiomyocyte Function.Cold Spring Harbor perspectives in biology · 2020Review
- IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency.Frontiers in cell and developmental biology · 2020Article
- Focused Ultrasound Stimulates ER Localized Mechanosensitive PANNEXIN-1 to Mediate Intracellular Calcium Release in Invasive Cancer Cells.Frontiers in cell and developmental biology · 2020Article
- Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Computational Model of Coupled Myocytes.Frontiers in physiology · 2020Article
- Arrhythmogenic Current Generation by Myofilament-Triggered CaBiophysical journal · 2019Article
- Temporal Impact of Substrate Anisotropy on Differentiating Cardiomyocyte Alignment and Functionality.Tissue engineering. Part A · 2019Article
- Acid-Sensitive Ion Channels Are Expressed in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Stem cells and development · 2019Article
- Transient receptor potential channels in cardiac health and disease.Nature reviews. Cardiology · 2019Review
- In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy.PLoS computational biology · 2018Article
- Sarcoplasmic reticulum CaPhysiological reports · 2018Article
- Article
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6 authors.
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Abstract
Early (E9.5-E11.5) embryonic heart cells beat spontaneously, even though the adult pacemaking mechanisms are not yet fully established. Here we show that in isolated murine early embryonic cardiomyocytes periodic oscillations of cytosolic Ca(2+) occur and that these induce contractions. The Ca(2+) oscillations originate from the sarcoplasmic reticulum and are dependent on the IP(3) and the ryanodine receptor. The Ca(2+) oscillations activate the Na(+)-Ca(2+) exchanger, giving rise to subthreshold depolarizations of the membrane potential and/or action potentials. Although early embryonic heart cells are voltage-independent Ca(2+) oscillators, the generation of action potentials provides synchronization of the electrical and mechanical signals. Thus, Ca(2+) oscillations pace early embryonic heart cells and the ensuing activation of the Na(+)-Ca(2+) exchanger evokes small membrane depolarizations or action potentials.
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