Evidence map›Paper›PMID 17664335›Full record

ArticleThe Journal of cell biology2007

An ACAP1-containing clathrin coat complex for endocytic recycling.

Jian Li, Peter J Peters, Ming Bai, Jun Dai, Erik Bos, Tomas Kirchhausen, Konstantin V Kandror, Victor W Hsu

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 129 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. GLUT4 On the move.The Biochemical journal · 2022
    Article
  18. Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Jian LiDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Peter J Peters
Ming Bai
Jun Dai
Erik Bos
Tomas Kirchhausen
Konstantin V Kandror
Victor W Hsu
Brigham and Women's Hospital · USThe Netherlands Cancer Institute · NLBoston University · USHarvard University · US

Funding

INSULIN REGULATION OF CELL NUTRITIONR01DK052057 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KANDROR, KONSTANTIN V · 1997 to 2023
$7.1M
Dynamics of Clathrin Coat Formation in CellsR01GM075252 · NIGMS · IMMUNE DISEASE INSTITUTE, INC. · PI KIRCHHAUSEN, TOMAS · 2005 to 2018
$4.6M
Cargo sorting during endocytic recyclingR01GM073016 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI HSU, VICTOR W · 2005 to 2013
$3.0M
Insulin regulation of cell nutritionR56DK052057 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KANDROR, KONSTANTIN V · 2008 to 2014
$418k
NIDDK NIH HHS DK052057NIDDK NIH HHS R01 DK052057NIDDK NIH HHS R56 DK052057NIGMS NIH HHS GM073016NIGMS NIH HHS GM075252NIGMS NIH HHS R01 GM073016NIGMS NIH HHS R01 GM075252
6 · The paper itself

Abstract

Whether coat proteins play a widespread role in endocytic recycling remains unclear. We find that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings, stimulation-dependent recycling of integrin that is critical for cell migration and insulin-stimulated recycling of glucose transporter type 4 (Glut4), which is required for glucose homeostasis. These findings not only advance a basic understanding of an early mechanistic step in endocytic recycling but also shed key mechanistic insights into major physiological events for which this transport plays a critical role.

Indexed as

3T3-L1 CellsADP-Ribosylation Factor 6ADP-Ribosylation FactorsAmino Acid SequenceAnimalsCell MembraneClathrinCoat Protein Complex IEndocytosisEndosomesGlucose Transporter Type 4GTPase-Activating ProteinsHumansIntegrinsMiceMolecular Sequence DataACAP1 protein, humanADP-Ribosylation Factor 6ADP-Ribosylation FactorsARF6 protein, humanArf6 protein, mouseClathrinCoat Protein Complex IGlucose Transporter Type 4GTPase-Activating ProteinsIntegrinsMultiprotein Complexes

Identifiers

PMID17664335
PMCPMC2064835
OpenAlexW2100979233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.