ArticleAntimicrobial agents and chemotherapy2007
Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- TheJournal of bacteriology · 2023Article
- Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The fitness cost of mismatch repair mutators in Saccharomyces cerevisiae: partitioning the mutational load.Heredity · 2020Article
- The Mutator Phenotype: Adapting Microbial Evolution to Cancer Biology.Frontiers in genetics · 2019Review
- Article
- Article
- Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains.BMC genomics · 2015Article
- Review
- Molecular Investigation of Quinolone Resistance of Quinolone Resistance-Determining Region in Streptococcus pneumoniae Strains Isolated from Iran Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method.Osong public health and research perspectives · 2014Article
- Normal mutation rate variants arise in a Mutator (Mut S) Escherichia coli population.PloS one · 2013Article
- Regulation of Helicobacter pylori adherence by gene conversion.Molecular microbiology · 2012Article
- Frequent beneficial mutations during single-colony serial transfer of Streptococcus pneumoniae.PLoS genetics · 2011Article
- Challenges of antibacterial discovery.Clinical microbiology reviews · 2011Review
- Genome dynamics in major bacterial pathogens.FEMS microbiology reviews · 2009Review
- Production of a unique pneumococcal capsule serotype belonging to serogroup 6.Microbiology (Reading, England) · 2009Article
- The rise and fall of bacterial clones: Streptococcus pneumoniae.Nature reviews. Microbiology · 2008Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The occurrence of mutator phenotypes among laboratory-generated and clinical levofloxacin-resistant strains of Streptococcus pneumoniae was determined using fluctuation analysis. The in vitro selection for levofloxacin-resistant mutants of strain D39, each with point mutations in both gyrA and parC or parE, was not associated with a significant change in the mutation rate. Two of eight clinical isolates resistant to levofloxacin (MIC, >8 microg/ml) had estimated mutation rates of 1.2 x 10(-7) and 9.4 x 10(-8) mutations per cell division, indicating potential mutator phenotypes, compared to strain D39, which had an estimated mutation rate of 1.4 x 10(-8) mutations per cell division. The levofloxacin-resistant isolates with the highest mutation rates showed evidence of dysfunctional mismatch repair and contained missense mutations in mut genes at otherwise highly conserved sites. The association of hypermutability in levofloxacin-resistant S. pneumoniae clinical isolates with mutations in DNA mismatch repair genes provides further evidence that mismatch repair mutants may have a selective advantage in the setting of antibiotic pressure, facilitating the development of further antibiotic resistance.
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