ArticleAntimicrobial agents and chemotherapy2007
The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Stress-Activated Protein Kinase Pathways as Potential Targets for the Development of New Antifungals.Journal of fungi (Basel, Switzerland) · 2026Review
- The Dual PathogenJournal of fungi (Basel, Switzerland) · 2025Review
- Functional analysis of theiScience · 2022Article
- Review
- Network analysis of hyphae forming proteins inHeliyon · 2019Article
- The yeasts phosphorelay systems: a comparative view.World journal of microbiology & biotechnology · 2017Review
- Disruption of the transcriptional regulator Cas5 results in enhanced killing of Candida albicans by Fluconazole.Antimicrobial agents and chemotherapy · 2014Article
- Colonization by Candida species of the oral and vaginal mucosa in HIV-infected and noninfected women.AIDS research and human retroviruses · 2013Article
- Two-component signal transduction proteins as potential drug targets in medically important fungi.Infection and immunity · 2008Review
- Transcriptional profiling of the Candida albicans Ssk1p receiver domain point mutants and their virulence.FEMS yeast research · 2008Article
- Contributions of the response regulators Ssk1p and Skn7p in the pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.Eukaryotic cell · 2008Article
- Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.Eukaryotic cell · 2008Review
- Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.Eukaryotic cell · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hypersensitivity to the triazoles fluconazole and voriconazole associated with two-component signal transduction proteins has not been reported in Candida albicans. Herein, we show that strains of C. albicans lacking the response regulator Ssk1p or the Chk1p histidine kinase signal transduction proteins are hypersensitive to fluconazole and voriconazole compared to wild-type (wt) as well as gene-reconstituted strains, reflecting an increased hypersensitivity to these drugs of about 16- to 500-fold. In comparison to wt cells, both mutants had elevated levels of fluconazole accumulation and reduced viability upon incubation with either drug, suggesting that in the absence of Ssk1p or Chk1p, fluconazole and voriconazole have significantly increased fungicidal effects on C. albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.