ArticleAntimicrobial agents and chemotherapy2007
Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Negamycin: Nature's Forgotten Antibiotic.ACS infectious diseases · 2026Review
- Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025Review
- The Development of a Sulfamate-Tethered Aza-Michael Cyclization Allows for the Preparation of (-)-NegamycinThe Journal of organic chemistry · 2024Article
- Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development.Biomolecules · 2023Review
- Identification and characterization of RNA pentaloop sequence families.NAR genomics and bioinformatics · 2023Article
- Recoding of Nonsense Mutation as a Pharmacological Strategy.Biomedicines · 2023Review
- Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine.Nucleic acids research · 2022Article
- Repurposing tRNAs for nonsense suppression.Nature communications · 2021Article
- Nonsense suppression therapies in human genetic diseases.Cellular and molecular life sciences : CMLS · 2021Review
- The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes.Antimicrobial agents and chemotherapy · 2021Article
- Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.Annual review of biochemistry · 2018Review
- Markerless Escherichia coli rrn Deletion Strains for Genetic Determination of Ribosomal Binding Sites.G3 (Bethesda, Md.) · 2015Article
- Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.Molecular cell · 2014Article
- Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.MedChemComm · 2014Article
- Article
- Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.Chemical communications (Cambridge, England) · 2010Article
- Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.Antimicrobial agents and chemotherapy · 2009Article
- U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.Journal of molecular biology · 2009Article
- Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Negamycin, a small-molecule inhibitor of protein synthesis, binds the Haloarcula marismortui 50S ribosomal subunit at a single site formed by highly conserved RNA nucleotides near the cytosolic end of the nascent chain exit tunnel. The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.