ArticleMolecular and cellular biology2007
The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Identification and functional analysis of ULP2 SUMO protease mutants of the stress-tolerant yeastmicroPublication biology · 2025Article
- Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.The Journal of cell biology · 2021Article
- Revised annotation and extended characterizations of components of thePlant direct · 2020Article
- The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation.The EMBO journal · 2019Article
- Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease.Nature communications · 2018Article
- SUMO targeting of a stress-tolerant Ulp1 SUMO protease.PloS one · 2018Article
- A high throughput mutagenic analysis of yeast sumo structure and function.PLoS genetics · 2017Article
- Roles of SUMO in Replication Initiation, Progression, and Termination.Advances in experimental medicine and biology · 2017Review
- SUMO Pathway Modulation of Regulatory Protein Binding at the Ribosomal DNA Locus in Saccharomyces cerevisiae.Genetics · 2016Article
- In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.The Journal of biological chemistry · 2015Article
- Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.Nature communications · 2015Article
- RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.The Journal of cell biology · 2013Article
- Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.The Journal of cell biology · 2013Article
- Function and regulation of SUMO proteases.Nature reviews. Molecular cell biology · 2012Review
- Sumoylation and the DNA damage response.Biomolecules · 2012Review
- Sumo-dependent substrate targeting of the SUMO protease Ulp1.BMC biology · 2011Article
- The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases.The Journal of biological chemistry · 2011Article
- The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.PLoS genetics · 2011Article
- Purification and identification of endogenous polySUMO conjugates.EMBO reports · 2011Article
- Genetic evidence that polysumoylation bypasses the need for a SUMO-targeted Ub ligase.Genetics · 2011Article
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Authors and funding
3 authors.
Funding
Abstract
Eukaryotic genome integrity is maintained via a DNA damage checkpoint that recognizes DNA damage and halts the cell cycle at metaphase, allowing time for repair. Checkpoint signaling is eventually terminated so that the cell cycle can resume. How cells restart cell division following checkpoint termination is poorly understood. Here we show that the SUMO protease Ulp2 is required for resumption of cell division following DNA damage-induced arrest in Saccharomyces cerevisiae, although it is not required for DNA double-strand break repair. The Rad53 branch of the checkpoint pathway generates a signal countered by Ulp2 activity following DNA damage. Interestingly, unlike previously characterized adaptation mutants, ulp2Delta mutants do not show persistent Rad53 phosphorylation following DNA damage, suggesting checkpoint signaling has been terminated and no longer asserts an arrest in these cells. Using Cdc14 localization as a cell cycle indicator, we show that nearly half of cells lacking Ulp2 can escape a checkpoint-induced metaphase arrest despite their inability to divide again. Moreover, half of permanently arrested ulp2Delta cells show evidence of an aberrant mitotic spindle, suggesting that Ulp2 is required for proper spindle dynamics during cell cycle resumption following a DNA damage-induced cell cycle arrest.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.