ArticleJournal of psychosomatic research2007
Depression following pegylated interferon-alpha: characteristics and vulnerability.
Article in Journal of psychosomatic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 101 citations in OpenAlex.
- Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue.Brain, behavior, and immunity · 2011Trial
- Management of Medication-Induced Psychiatric Disorders.Indian journal of psychiatry · 2022Article
- Between Personality Traits and Postpartum Depression: The Mediated Role of Maternal Self-Efficacy.Neuropsychiatric disease and treatment · 2022Article
- Moderators of inflammation-related depression: a prospective study of breast cancer survivors.Translational psychiatry · 2021Article
- The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders.Nutrients · 2021Review
- The role of cap-dependent translation in aged-related changes in neuroimmunity and affective behaviors.Neurobiology of aging · 2021Article
- Effect of Pegylated Interferon and Mitomycin C on Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum: A Case Series.The American journal of case reports · 2020Article
- Executive Control, Cytokine Reactivity to Social Stress, and Depressive Symptoms: Testing the Social Signal Transduction Theory of Depression.Stress (Amsterdam, Netherlands) · 2020Article
- The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation.Neuroscience and biobehavioral reviews · 2018Review
- Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C.Psychiatry investigation · 2017Article
- Role of inflammatory cytokines in depression: Focus on interleukin-1β.Biomedical reports · 2017Article
- Functional Polymorphism in the Interleukin 6 (IL6) Gene with Respect to Depression Induced in the Course of Interferon-α and Ribavirin Treatment in Chronic Hepatitis Patients.Archivum immunologiae et therapiae experimentalis · 2016Article
- Treatment-emergent depression and anxiety between peginterferon alpha-2a versus alpha-2b plus ribavirin for chronic hepatitis C.BMC psychiatry · 2016Observational
- Transcriptomics in Interferon-α-Treated Patients Identifies Inflammation-, Neuroplasticity- and Oxidative Stress-Related Signatures as Predictors and Correlates of Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- The Immune System and the Role of Inflammation in Perinatal Depression.Neuroscience bulletin · 2016Review
- Minocycline attenuates interferon-α-induced impairments in rat fear extinction.Journal of neuroinflammation · 2016Article
- The Effect of Combination Antiviral Therapy in the Treatment of Hepatitis C on the Occurrence of Depressive Disorder in Patients Treated for Hepatitis C in the Republic of Srpska.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression.The international journal of neuropsychopharmacology · 2016Article
- Polyunsaturated fatty acids moderate the effect of poor sleep on depression risk.Prostaglandins, leukotrienes, and essential fatty acids · 2016Article
- Association of Baseline Sleep Quality With Trajectories of Depressive Symptoms in Patients Undergoing Interferon Treatment.Psychosomatic medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveInterferon-alpha2 (IFN-alpha) injections may be capable of triggering depression in some individuals. The first objective was to further characterize this depression and, secondly, to examine whether pre-treatment temperament was correlated with subsequent vulnerability to IFN-alpha.
methodsTwenty-three initially euthymic adults undergoing year-long PEG-IFN-alpha treatment for hepatitis C were evaluated at baseline and then prospectively monitored using both the Structured Clinical Interview for DSM-IV (SCID) and self-report questionnaires.
resultsA major depressive episode developed within 3 months in 39%. Principal component analysis of the change in self-report scores after 1 month of treatment demonstrated three orthogonal factors: (i) a specific increase in depression as manifested in the Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS), (ii) an increase in hostility and anxiety, (iii) and a generalized combination of worse symptoms including somatic symptoms on the Symptom Check List (SCL-90). BDI at 1 month was predicted by baseline BDI (r=0.76, P=.004). Hostility at 1 month was predicted by low baseline agreeableness (r=0.75, P=.01). Controlling for baseline BDI scores, categorical major depression was predicted by combined high baseline neuroticism and low agreeableness (combined r=0.66, P=.03).
conclusionThese initial results (i) support the depressogenic nature of IFN-alpha treatment in a subset of vulnerable individuals, (ii) indicate that some individuals are also independently vulnerable to worsened hostility, and (iii) suggest that it may be possible to clinically predict these vulnerabilities in initially euthymic subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.