Evidence map›Paper›PMID 17662717›Full record

ReviewExperimental neurology2008

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury.

Dustin J Donnelly, Phillip G Popovich

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 524 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
524citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

524 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  17. [Effect of composite graphene-protein hydrogels on neural regeneration after spinal cord injury in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
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464 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dustin J DonnellyThe Integrated Biomedical Science Graduate Program, Department of Molecular Virology, Immunology & Medical Genetics, The Center for Brain and Spinal Cord Repair, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Phillip G Popovich

Funding

MACROPHAGE HETEROGENEITY AFTER SPINAL CORD INJURYR01NS037846 · NINDS · OHIO STATE UNIVERSITY · PI POPOVICH, PHILLIP G · 1999 to 2008
$2.7M
NINDS NIH HHS NS 746703NINDS NIH HHS R01 NS037846
6 · The paper itself

Abstract

Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based therapies are becoming a therapeutic focus. This review will address the complexities and controversies of post-traumatic neuroinflammation, particularly in spinal cord. In addition, current therapies designed to target neuroinflammatory cascades will be discussed.

Indexed as

Spinal Cord InjuriesAnimalsAxonsHumansInflammationRecovery of FunctionRegeneration

Identifiers

PMID17662717
PMCPMC2692462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.