ArticleExperimental eye research2007
Streptozotocin-induced diabetes modulates GABA receptor activity of rat retinal neurons.
Article in Experimental eye research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Retinal VIP-amacrine cells: their development, structure, and function.Eye (London, England) · 2024Pooled it
- Discovery of novel quinazoline-sulfonamide derivatives with promising antidiabetic activity.Frontiers in chemistry · 2026Article
- From Neurotransmission to Retinal Pathophysiology: Unraveling the Role of GABA Receptors in Retinal Disease Progression.Journal of neurochemistry · 2025Review
- Role of γ-Aminobutyric Acid (GABA) as an Inhibitory Neurotransmitter in Diabetes Management: Mechanisms and Therapeutic Implications.Biomolecules · 2025Review
- Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period.Cellular and molecular neurobiology · 2024Article
- Function of the GABAergic System in Diabetic Encephalopathy.Cellular and molecular neurobiology · 2023Review
- Design, Synthesis, Molecular Modeling and Anti-Hyperglycemic Evaluation of Quinazoline-Sulfonylurea Hybrids as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Sulfonylurea Receptor (SUR) Agonists.International journal of molecular sciences · 2022Article
- Time dependent effects of prolonged hyperglycemia in zebrafish brain and retina.Frontiers in ophthalmology · 2022Article
- Rod phototransduction and light signal transmission during type 2 diabetes.BMJ open diabetes research & care · 2020Article
- Differential Modulation of GABAFrontiers in molecular neuroscience · 2017Article
- Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.Investigative ophthalmology & visual science · 2016Article
- Identification of type 2 diabetes subgroups through topological analysis of patient similarity.Science translational medicine · 2015Article
- Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Rodent Hyperglycemia-Induced Inner Retinal Deficits are Mirrored in Human Diabetes.Translational vision science & technology · 2014Article
- Early visual deficits in streptozotocin-induced diabetic long evans rats.Investigative ophthalmology & visual science · 2013Article
- Identifying cell class specific losses from serially generated electroretinogram components.BioMed research international · 2013Article
- Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.Nature communications · 2012Article
- Potentiating action of propofol at GABAA receptors of retinal bipolar cells.Investigative ophthalmology & visual science · 2011Article
- Neurovascular interaction and the pathophysiology of diabetic retinopathy.Experimental diabetes research · 2011Review
- Protective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother rats.International journal of biological sciences · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Neural deficits suggestive of involvement of the GABA signaling pathway can often be detected early in the course of diabetic retinopathy, a leading cause of blindness in the United States. To examine in greater detail the nature of the neuronal changes associated with hyperglycemia, we investigated GABA receptor activity on retinal bipolar cells in streptozotocin-induced diabetic rats; cells from age-matched normal rats served as controls. Patch-clamp recordings from isolated rod-bipolar cells revealed that diabetes enhanced the whole cell currents elicited by GABA. Responses of the GABA(C) receptor, the predominant GABA receptor on rat rod bipolar cells, exhibited a greater sensitivity to GABA, larger maximum current responses, slower response kinetics, and a smaller single channel conductance among diabetic cells relative to those recorded from normal controls. Compared with the properties of homomeric rho1 and heteromeric rho1rho2 receptors formed in a heterologous expression system, these results suggested that there was a greater contribution from the rho1 subunit in the GABA(C) receptor-mediated response of diabetic cells. The levels of mRNA, measured with real-time RT-PCR, were consistent with this finding. There was a significant enhancement in the ratio of rho1/rho2 subunit expression in the retina of diabetic animals, although the levels of GABA rho1 subunit expression were comparable in diabetic and normal retinas. Taken together, the results suggest that diabetes modifies the subunit composition of the GABA(C) receptor on retinal neurons, most likely through its effect on the efficacy of gene transcription.
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