ReviewProgress in retinal and eye research2007
Cochlin in the eye: functional implications.
Review in Progress in retinal and eye research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Loss ofMatrix biology plus · 2025Article
- Loss ofbioRxiv : the preprint server for biology · 2024Article
- Targeting the cochlin/SFRP1/CaMKII axis in the ocular posterior pole prevents the progression of nonpathologic myopia.Communications biology · 2023Article
- Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss.International journal of molecular sciences · 2021Article
- Aqueous outflow regulation - 21st century concepts.Progress in retinal and eye research · 2021Review
- Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation.BMB reports · 2020Review
- Computational analysis based on audioprofiles: A new possibility for patient stratification in office-based otology.Audiology research · 2019Article
- The Price of Immune Responses and the Role of Vitamin D in the Inner Ear.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019Review
- Bi-allelic inactivating variants in the COCH gene cause autosomal recessive prelingual hearing impairment.European journal of human genetics : EJHG · 2018Article
- Interaction of cochlin and mechanosensitive channel TREK-1 in trabecular meshwork cells influences the regulation of intraocular pressure.Scientific reports · 2017Article
- Aqueous outflow - A continuum from trabecular meshwork to episcleral veins.Progress in retinal and eye research · 2017Review
- In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography.Scientific reports · 2015Article
- Analysis of COCH and TNFA variants in East Indian primary open-angle glaucoma patients.BioMed research international · 2013Article
- Cochlin, intraocular pressure regulation and mechanosensing.PloS one · 2012Article
- Extralabyrinthine manifestations of DFNA9.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility.PloS one · 2011Article
- Biomarkers of primary open-angle glaucoma.Expert review of ophthalmology · 2010Article
- COCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey organ cultured anterior segments.Investigative ophthalmology & visual science · 2010Article
- Potential for transcriptional upregulation of cochlin in glaucomatous trabecular meshwork: a combinatorial bioinformatic and biochemical analytical approach.Investigative ophthalmology & visual science · 2009Article
- Cochlin expression in anterior segment organ culture models after TGFbeta2 treatment.Investigative ophthalmology & visual science · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Aqueous humor is actively produced in the ciliary epithelium of the anterior chamber and has important functions for the eye. Under normal physiological conditions, the inflow and outflow of the aqueous humor are tightly regulated, but in the pathologic state this balance is lost. Aqueous outflow involves structures of the anterior chamber and experiences most resistance at the level of the trabecular meshwork (TM) that acts as a filter. The modulation of the TM structure regulates the filter and its mechanism remains poorly understood. Proteomic analyses have identified cochlin, a protein of poorly understood function, in the glaucomatous TM but not in healthy control TM from human cadaver eyes. The presence of cochlin has subsequently been confirmed by Western and immunohistochemical analyses. Functionally, cochlin undergoes multimerization induced by shear stress and other changes in the microenvironment. Cochlin along with mucopolysaccharide deposits has been found in the TM of glaucoma patients and in the inner ear of subjects affected by the hearing disorder DNFA9, a late-onset, progressive disease that also involves alterations in fluid shear regimes. In vitro, cochlin induces aggregation of primary TM cells suggesting a role in cell adhesion, possibly in mechanosensation, and in modulation of the TM filter.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.