Trial reportSchizophrenia research2007
Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial.
Trial report in Schizophrenia research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Risperidone versus other atypical antipsychotics for schizophrenia.The Cochrane database of systematic reviews · 2011Pooled it
- Olanzapine versus other atypical antipsychotics for schizophrenia.The Cochrane database of systematic reviews · 2010Pooled it
- Predictors of smoking reduction outcomes in a sample of 287 patients with schizophrenia spectrum disorders.European archives of psychiatry and clinical neuroscience · 2017Trial
- Methylphenidate enhances prepulse inhibition during processing of task-relevant stimuli in attention-deficit/hyperactivity disorder.Psychophysiology · 2010Trial
- Prepulse inhibition of startle in adults with ADHD.Journal of psychiatric research · 2009Trial
- The Effect of Glutathione Deficit During Early Postnatal Brain Development on the Prepulse Inhibition and Monoamine Levels in Brain Structures of Adult Sprague-Dawley Rats.Neurotoxicity research · 2022Article
- Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia.Frontiers in behavioral neuroscience · 2022Review
- Insights About Striatal Circuit Function and Schizophrenia From a Mouse Model of Dopamine DBiological psychiatry · 2017Review
- Voluntary emotion regulation in anorexia nervosa: A preliminary emotion-modulated startle investigation.Journal of psychiatric research · 2016Article
- Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy.Frontiers in pharmacology · 2016Review
- Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon.Scientific reports · 2015Article
- Effects of dopamine D2/D3 blockade on human sensory and sensorimotor gating in initially antipsychotic-naive, first-episode schizophrenia patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS.Schizophrenia research · 2014Article
- The relationship between acoustic startle response measures and cognitive functions in Japanese patients with schizophrenia.Neuromolecular medicine · 2012Article
- Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia.PloS one · 2012Article
- Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2011Article
- Startle reactivity and prepulse inhibition in prodromal and early psychosis: effects of age, antipsychotics, tobacco and cannabis in a vulnerable population.Psychiatry research · 2011Article
- Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Lack of relationship between acoustic startle and cognitive variables in schizophrenia and control subjects.Psychiatry research · 2011Article
- No association between prepulse inhibition of the startle reflex and neuropsychological deficit in chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
Prepulse inhibition (PPI), whereby the startle eyeblink response is inhibited by a relatively weak non-startling stimulus preceding the powerful startle eliciting stimulus, is a measure of sensorimotor gating and has been shown to be deficient in schizophrenia patients. There is considerable interest in whether conventional and/or atypical antipsychotic medications can "normalize" PPI deficits in schizophrenia patients. 51 schizophrenia patients participated in a randomized, double-blind controlled trial on the effects of three commonly-prescribed antipsychotic medications (risperidone, olanzapine, or haloperidol) on PPI, startle habituation, and startle reactivity. Patients were tested at baseline, Week 4 and Week 8. Mixed model regression analyses revealed that olanzapine significantly improved PPI from Week 4 to Week 8, and that at Week 8 patients receiving olanzapine produced significantly greater PPI than those receiving risperidone, but not haloperidol. There were no effects of medication on startle habituation or startle reactivity. These results support the conclusion that olanzapine effectively increased PPI in schizophrenia patients, but that risperidone and haloperidol had no such effects. The results are discussed in terms of animal models, neural substrates, and treatment implications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.