ArticleCurrent genetics2007
Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature.
Article in Current genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Importance of Clinical Isolates inJournal of fungi (Basel, Switzerland) · 2023Review
- Coccidioides Species: A Review of Basic Research: 2022.Journal of fungi (Basel, Switzerland) · 2022Review
- Repair of Iron Center Proteins-A Different Class of Hemerythrin-like Proteins.Molecules (Basel, Switzerland) · 2022Review
- Dnj1 Promotes Virulence inFrontiers in microbiology · 2021Article
- Basic principles of the virulence ofVirulence · 2019Review
- The Di-iron RIC Protein (YtfE) of Escherichia coli Interacts with the DNA-Binding Protein from Starved Cells (Dps) To Diminish RIC Protein-Mediated Redox Stress.Journal of bacteriology · 2018Article
- Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans.Genetics · 2017Article
- Systems Biology Approaches for Host-Fungal Interactions: An Expanding Multi-Omics Frontier.Omics : a journal of integrative biology · 2016Review
- Article
- Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating.Fungal genetics and biology : FG & B · 2014Article
- Article
- Hemoglobin: a nitric-oxide dioxygenase.Scientifica · 2012Review
- Genome-wide analysis of the RING finger gene family in apple.Molecular genetics and genomics : MGG · 2011Article
- Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans.Eukaryotic cell · 2011Article
- A novel specificity protein 1 (SP1)-like gene regulating protein kinase C-1 (Pkc1)-dependent cell wall integrity and virulence factors in Cryptococcus neoformans.The Journal of biological chemistry · 2011Article
- Blastomyces dermatitidis yeast cells inhibit nitric oxide production by alveolar macrophage inducible nitric oxide synthase.Infection and immunity · 2011Article
- A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans.Cell host & microbe · 2011Article
- Article
- Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase.Eukaryotic cell · 2010Article
- Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs.Molecular microbiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptococcus neoformans var grubii is an opportunistic basidiomycete yeast pathogen that is a significant cause of HIV/AIDS-related deaths worldwide. We describe a whole-genome oligonucleotide microarray for this pathogen. These arrays have been used to elucidate the transcriptional responses of the genome to heat shock as well as to two conditions relevant to human infections: body temperature and nitric oxide (NO) stress produced by the NO donor DPTA-NONOate. This analysis revealed an NO-inducible C. neoformans-specific four-gene family that showed a highly similar transcriptional profile to that of FHB1, a previously described NO dioxygenase/flavohemoglobin required for virulence. NO treatment also induced genes involved in the synthesis of the antioxidant mannitol, a polyol that accumulates in the cerebrospinal fluid of infected patients. Exposure to NO also caused increased expression of the sole C. neoformans var grubii protein with HHE/hemerythrin cation binding motifs. Notably, a similar gene in E. coli, ytfE, has been shown to be NO-inducible and protects bacterial cells from killing by NO. Genes induced by NO were highly enriched for those repressed at 37 degrees C, indicating an unexpected interplay between temperature and NO regulation in this basidiomycete. Resources described here should facilitate future investigations of this lethal human yeast pathogen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.