ArticleJapanese journal of ophthalmology
Keratitis caused by a rare fungus, Malassezia restricta.
Article in Japanese journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis.Translational vision science & technology · 2025Pooled it
- A Repertoire of the Less Common Clinical Yeasts.Journal of fungi (Basel, Switzerland) · 2023Review
- Assessment of genotypes, endosymbionts and clinical characteristics of Acanthamoeba recovered from ocular infection.BMC infectious diseases · 2022Article
- Review
- Protective effect of miconazole on rat myelin sheaths following premature infant cerebral white matter injury.Experimental and therapeutic medicine · 2018Article
- Malassezia pachydermatis keratomycosis in a dog.Medical mycology case reports · 2015Article
- Prolonged fever and splenic lesions caused by Malassezia restricta in an immunocompromised patient.Pediatric transplantation · 2014Article
- Eukaryotic diversity in premise drinking water using 18S rDNA sequencing: implications for health risks.Environmental science and pollution research international · 2013Article
- The Malassezia genus in skin and systemic diseases.Clinical microbiology reviews · 2012Review
- Evaluation of molecular diagnosis in fungal keratitis. Ten years of experience.Journal of ophthalmic inflammation and infection · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalassezia species rarely cause keratitis, and, thus, the clinical manifestations of Malassezia keratitis are not well known. CASE: We report the clinical findings in a 70-year-old woman who complained of pain in her left eye. Slit-lamp biomicroscopy showed a corneal ulcer with irregular infiltration, which resembled keratitis caused by filamentous fungi. KOH Parker ink stain of a corneal scraping showed mold hyphae and yeast, but cultures on Sabouraud's glucose agar plates and blood agar plates were negative. Treatment with antibacterial agents failed. OBSERVATIONS: Polymerase chain reaction (PCR) and DNA typing of the fungal gene between the internal transcribed spacer 2 (ITS2) and the 5.8S ribosomal DNA of the scraping were performed. PCR amplified a band with a sequence that was 99% homologous with Malassezia restricta. Antifungal agents, topical 5% pimaricin ointment and 0.2% miconazole, and oral itraconazole 150 mg/day, were applied, and the corneal ulcer disappeared within 5 weeks.
conclusionMalassezia restricta can cause keratitis, and the clinical findings resemble keratitis caused by filamentous fungi. PCR and DNA typing of ITS2 and 5.8S ribosomal DNA are valuable techniques for detecting and identifying Malassezia species. Proper identification of Malassezia keratitis permits a prompt and successful treatment by antifungal agents.
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