ArticleGenetics2007
Bird and mammal sex-chromosome orthologs map to the same autosomal region in a salamander (ambystoma).
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- The role of unbalanced segmental duplication in sex chromosome evolution in Australian ridge-tailed goannas.Scientific reports · 2025Article
- Sex chromosome evolution among amniotes: is the origin of sex chromosomes non-random?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Whole genome-wide chromosome fusion and new gene birth in theCell & bioscience · 2020Article
- Miniscule differences between sex chromosomes in the giant genome of a salamander.Scientific reports · 2018Article
- DNA methylation and expression of proopiomelanocortin (FEBS open bio · 2018Article
- A syntenic region conserved from fish to Mammalian x chromosome.International journal of evolutionary biology · 2014Article
- Gene expression and DNA methylation status of chicken primordial germ cells.Molecular biotechnology · 2013Article
- Are some chromosomes particularly good at sex? Insights from amniotes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Article
- First-generation linkage map for the common frog Rana temporaria reveals sex-linkage group.Heredity · 2011Article
- Strong conservation of the bird Z chromosome in reptilian genomes is revealed by comparative painting despite 275 million years divergence.Chromosoma · 2011Article
- Origin of amphibian and avian chromosomes by fission, fusion, and retention of ancestral chromosomes.Genome research · 2011Article
- Non-homologous sex chromosomes of birds and snakes share repetitive sequences.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition.Nature · 2010Article
- Are homologies in vertebrate sex determination due to shared ancestry or to limited options?Genome biology · 2010Review
- New resources inform study of genome size, content, and organization in nonavian reptiles.Integrative and comparative biology · 2008Article
- Comparative chromosome mapping of sex-linked genes and identification of sex chromosomal rearrangements in the Japanese wrinkled frog (Rana rugosa, Ranidae) with ZW and XY sex chromosome systems.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We tested hypotheses concerning the origin of bird and mammal sex chromosomes by mapping the location of amniote sex-chromosome loci in a salamander amphibian (Ambystoma). We found that ambystomatid orthologs of human X and chicken Z sex chromosomes map to neighboring regions of a common Ambystoma linkage group 2 (ALG2). We show statistically that the proportion of human X and chicken Z orthologs observed on ALG2 is significantly different from the proportion that would be expected by chance. We further show that conserved syntenies between ALG2 and amniote chromosomes are identified as overlapping conserved syntenies when all available chicken (N = 3120) and human (N = 14,922) RefSeq orthologs are reciprocally compared. In particular, the data suggest that chromosomal regions from chicken chromosomes (GGA) Z and 4 and from human chromosomes (HSA) 9, 4, X, 5, and 8 were linked ancestrally. A more distant outgroup comparison with the pufferfish Tetraodon nigroviridis reveals ALG2/GGAZ/HSAX syntenies among three pairs of ancestral chromosome duplicates. Overall, our results suggest that sex chromosomal regions of birds and mammals were recruited from a common ancestral chromosome, and thus our findings conflict with the currently accepted hypothesis of separate autosomal origins. We note that our results were obtained using the most immediate outgroup to the amniote clade (mammals, birds, and other reptiles) while the currently accepted hypothesis is primarily based upon conserved syntenies between in-group taxa (birds and mammals). Our study illustrates the importance of an amphibian outgroup perspective in identifying ancestral amniote gene orders and in reconstructing patterns of vertebrate sex-chromosome evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.