ArticleGenetics2007
Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed.
- Evolution of Virus-like Features and Intrinsically Disordered Regions in Retrotransposon-derived Mammalian Genes.Molecular biology and evolution · 2024Article
- NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.Cellular & molecular biology letters · 2024Article
- Single-cell sequencing reveals transcriptional dynamics regulated by ERα in mouse ovaries.PloS one · 2024Article
- A single-cell atlas of the cycling murine ovary.eLife · 2022Article
- Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation.Cell death and differentiation · 2022Article
- Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Review
- Extended adverse effects of cyclophosphamide on mouse ovarian function.BMC pharmacology & toxicology · 2021Article
- Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression.Molecular medicine (Cambridge, Mass.) · 2020Article
- Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes.Cell proliferation · 2020Article
- PNMA5 knockdown suppresses the proliferation, invasion, and metastasis of epithelial ovarian cancer cells.Translational cancer research · 2020Article
- The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a female fertility factor required for oocyte quality and meiosis.Cell proliferation · 2020Article
- Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries).Mammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2019Article
- Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage.Biology of reproduction · 2018Article
- Identification of molecular pathways and candidate genes associated with cocks' comb size trait by genome-wide transcriptome analysis.Scientific reports · 2018Article
- The Effect of Anti-aging Peptides on Mechanical and Biological Properties of HaCaT Keratinocytes.International journal of peptide research and therapeutics · 2018Article
- Activation of β-catenin causes defects in embryonic development during maternal-to-zygotic transition in mice.International journal of clinical and experimental pathology · 2018Article
- Pnma5 is essential to the progression of meiosis in mouse oocytes through a chain of phosphorylation.Oncotarget · 2017Article
- Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation.Stem cell reports · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Female infertility syndromes are among the most prevalent chronic health disorders in women, but their genetic basis remains unknown because of uncertainty regarding the number and identity of ovarian factors controlling the assembly, preservation, and maturation of ovarian follicles. To systematically discover ovarian fertility genes en masse, we employed a mouse model (Foxo3) in which follicles are assembled normally but then undergo synchronous activation. We developed a microarray-based approach for the systematic discovery of tissue-specific genes and, by applying it to Foxo3 ovaries and other samples, defined a surprisingly large set of ovarian factors (n = 348, approximately 1% of the mouse genome). This set included the vast majority of known ovarian factors, 44% of which when mutated produce female sterility phenotypes, but most were novel. Comparative profiling of other tissues, including microdissected oocytes and somatic cells, revealed distinct gene classes and provided new insights into oogenesis and ovarian function, demonstrating the utility of our approach for tissue-specific gene discovery. This study will thus facilitate comprehensive analyses of follicle development, ovarian function, and female infertility.
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Registered trials
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