ArticleGenetics2007
Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- A novel method of using Deep Belief Networks and genetic perturbation data to search for yeast signaling pathways.PloS one · 2018Article
- Multi-BRCT scaffolds use distinct strategies to support genome maintenance.Cell cycle (Georgetown, Tex.) · 2016Review
- The Role of Mms22p in DNA Damage Response in Candida albicans.G3 (Bethesda, Md.) · 2015Article
- Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.Molecular cell · 2015Article
- Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.G3 (Bethesda, Md.) · 2015Article
- TORC2 is required to maintain genome stability during S phase in fission yeast.The Journal of biological chemistry · 2013Article
- Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific ChIP-seq method.Genome research · 2013Article
- Mms1 and Mms22 stabilize the replisome during replication stress.Molecular biology of the cell · 2011Article
- The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.Molecular cell · 2010Article
- Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.PLoS genetics · 2010Article
- Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks.Cell cycle (Georgetown, Tex.) · 2010Review
- Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing.The Journal of biological chemistry · 2010Article
- gammaH2A binds Brc1 to maintain genome integrity during S-phase.The EMBO journal · 2010Article
- Article
- Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.The EMBO journal · 2008Article
- Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase.Molecular biology of the cell · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The faithful replication of the genome, coupled with the accurate repair of DNA damage, is essential for the maintenance of chromosomal integrity. The MMS22 gene of Saccharomyces cerevisiae plays an important but poorly understood role in preservation of genome integrity. Here we describe a novel gene in Schizosaccharomyces pombe that we propose is a highly diverged ortholog of MMS22. Fission yeast Mms22 functions in the recovery from replication-associated DNA damage. Loss of Mms22 results in the accumulation of spontaneous DNA damage in the S- and G2-phases of the cell cycle and elevated genomic instability. There are severe synthetic interactions involving mms22 and most of the homologous recombination proteins but not the structure-specific endonuclease Mus81-Eme1, which is required for survival of broken replication forks. Mms22 forms spontaneous nuclear foci and colocalizes with Rad22 in cells treated with camptothecin, suggesting that it has a direct role in repair of broken replication forks. Moreover, genetic interactions with components of the DNA replication fork suggest that Mms2 functions in the coordination of DNA synthesis following damage. We propose that Mms22 functions directly at the replication fork to maintain genomic integrity in a pathway involving Mus81-Eme1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.