ArticleJournal of medical genetics2007
A genome-wide scan for genes involved in primary vesicoureteric reflux.
Article in Journal of medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Case report: A novel compound heterozygous variant in theFrontiers in endocrinology · 2024Article
- A successful centre for translational paediatric surgical research.Pediatric surgery international · 2022Review
- Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.PloS one · 2022Article
- A genome-wide scan to locate regions associated with familial vesicoureteral reflux.Experimental and therapeutic medicine · 2022Article
- DNA copy number variations in children with vesicoureteral reflux and urinary tract infections.PloS one · 2019Article
- Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.Scientific reports · 2017Article
- Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study.Familial cancer · 2017Article
- Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFβ1 and GNB3 with the occurrence of primary vesicoureteral reflux.International urology and nephrology · 2017Article
- Genetics of Vesicoureteral Reflux.Current genomics · 2016Article
- Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.Pediatric nephrology (Berlin, Germany) · 2016Article
- A new genome scan for primary nonsyndromic vesicoureteric reflux emphasizes high genetic heterogeneity and shows linkage and association with various genes already implicated in urinary tract development.Molecular genetics & genomic medicine · 2014Article
- A single-center cohort of Canadian children with VUR reveals renal phenotypes important for genetic studies.Pediatric nephrology (Berlin, Germany) · 2013Article
- TNXB mutations can cause vesicoureteral reflux.Journal of the American Society of Nephrology : JASN · 2013Article
- Genes in the ureteric budding pathway: association study on vesico-ureteral reflux patients.PloS one · 2012Article
- Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect.Pediatric nephrology (Berlin, Germany) · 2011Article
- Genetics of vesicoureteral reflux.Nature reviews. Urology · 2011Review
- Primary, nonsyndromic vesicoureteric reflux and nephropathy in sibling pairs: a United Kingdom cohort for a DNA bank.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2.PloS one · 2011Article
- A genome scan in affected sib-pairs with familial vesicoureteral reflux identifies a locus on chromosome 5.European journal of human genetics : EJHG · 2010Article
- Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.Journal of the American Society of Nephrology : JASN · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVesicoureteric reflux (VUR) is the retrograde flow of urine from the bladder into the ureters. It is the most common urological anomaly in children, and a major cause of end-stage renal failure and hypertension in both children and adults. VUR is seen in approximately 1-2% of Caucasian newborns and is frequently familial. OBJECTIVE AND
methodsIn order to search for genetic loci involved in VUR, we performed a genome-wide linkage scan using 4710 single-nucleotide polymorphisms (SNPs) in 609 individuals from 129 Irish families with >1 affected member.
resultsNonparametric linkage (NPL) analysis of the dataset yielded moderately suggestive linkage at chromosome 2q37 (NPL(max) = 2.67, p<0.001). Analysis of a subset without any additional features, such as duplex kidneys, yielded a maximum NPL score of 4.1 (p = 0.001), reaching levels of genome-wide statistical significance. Suggestive linkage was also seen at 10q26 and 6q27, and there were several smaller peaks.
conclusionOur results confirm the previous conclusion that VUR is genetically heterogeneous, and support the identification of several disease-associated regions indicated by smaller studies, as well as indicating new regions of interest for investigation.
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