ArticleJournal of medical genetics2007
Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease.
Article in Journal of medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Meta-analysis of 32 genome-wide linkage studies of schizophrenia.Molecular psychiatry · 2009Pooled it
- Effect of communicating DNA based risk assessments for Crohn's disease on smoking cessation: randomised controlled trial.BMJ (Clinical research ed.) · 2012Trial
- Trial Protocol: Communicating DNA-based risk assessments for Crohn's disease: a randomised controlled trial assessing impact upon stopping smoking.BMC public health · 2011Trial
- The impact of genetic testing for Crohn's disease, risk magnitude and graphical format on motivation to stop smoking: an experimental analogue study.Clinical genetics · 2008Trial
- Association between vaccine-induced immune thrombocytopenia and thrombosis and human leucocyte antigen loci: Yes, no or maybe?British journal of haematology · 2026Article
- The relationship between the severity of inflammatory bowel diseases and expirium air carbon monoxide levels.International journal of colorectal disease · 2023Article
- Theoretical Framework for the Study of Genetic Diseases Caused by Dominant Alleles.Life (Basel, Switzerland) · 2023Article
- Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn's Disease and Ulcerative Colitis.Frontiers in immunology · 2018Review
- Genetic and environmental components of family history in type 2 diabetes.Human genetics · 2015Article
- Nutritional Modulation of Gene Expression: Might This be of Benefit to Individuals with Crohn's Disease?Frontiers in immunology · 2015Review
- An envirogenomic signature is associated with risk of IBD-related surgery in a population-based Crohn's disease cohort.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013Article
- High-performance metabolic profiling with dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) for study of the exposome.Metabolomics : Official journal of the Metabolomic Society · 2013Article
- REGENT: a risk assessment and classification algorithm for genetic and environmental factors.European journal of human genetics : EJHG · 2013Article
- Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening.American journal of human genetics · 2011Article
- Growth of M. avium subspecies paratuberculosis in culture is enhanced by nicotinic acid, nicotinamide, and α and β nicotinamide adenine dinucleotide.Digestive diseases and sciences · 2011Article
- Interpretation of association signals and identification of causal variants from genome-wide association studies.American journal of human genetics · 2010Article
- Advances in the genetics of schizophrenia: will high-risk copy number variants be useful in clinical genetics or diagnostics?F1000 medicine reports · 2009Article
- Article
- A short-oligonucleotide microarray that allows improved detection of gastrointestinal tract microbial communities.BMC microbiology · 2008Article
- Explaining behavior change after genetic testing: the problem of collinearity between test results and risk estimates.Genetic testing · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundProgress has been made in identifying mutations that confer susceptibility to complex diseases, with the prospect that these genetic risks might be used in determining individual disease risk.
aimTo use Crohn disease (CD) as a model of a common complex disorder, and to develop methods to estimate disease risks using both genetic and environmental risk factors.
methodsThe calculations used three independent risk factors: CARD15 genotype (conferring a gene dosage effect on risk), smoking (twofold increased risk for smokers), and residual familial risk (estimating the effect of unidentified genes, after accounting for the contribution of CARD15). Risks were estimated for high-risk people who are siblings, parents and offspring of a patient with CD.
resultsThe CD risk to the sibling of a patient with CD who smokes and carries two CARD15 mutations is approximately 35%, which represents a substantial increase on the population risk of 0.1%. In contrast, the risk to a non-smoking sibling of a patient with CD who carries no CARD15 mutations is 2%. Risks to parents and offspring were lower.
conclusionsHigh absolute risks of CD disease can be obtained by incorporating information on smoking, family history and CARD15 mutations. Behaviour modification through smoking cessation may reduce CD risk in these people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.