ArticleAmerican journal of physiology. Heart and circulatory physiology2007
Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome.
Article in American journal of physiology. Heart and circulatory physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Trial
- Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects.Hypertension (Dallas, Tex. : 1979) · 2013Trial
- Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress.The Journal of physiology · 2012Trial
- Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans.The Journal of physiology · 2010Trial
- Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.American journal of physiology. Heart and circulatory physiology · 2008Trial
- Standing under pressure: hemodynamic effects of abdominal compression type and intensity in healthy adults.Frontiers in physiology · 2025Article
- Anticipatory central command on standing decreases cerebral blood velocity causing hypocapnia in hyperpneic postural tachycardia syndrome.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Ten days of repeated local forearm heating does not affect cutaneous vascular function.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Postsynaptic α1-Adrenergic Vasoconstriction Is Impaired in Young Patients With Vasovagal Syncope and Is Corrected by Nitric Oxide Synthase Inhibition.Circulation. Arrhythmia and electrophysiology · 2016Article
- Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance.Current neurology and neuroscience reports · 2015Review
- Comparison of the noradrenergic sympathetic nerve contribution during local skin heating at forearm and leg sites in humans.European journal of applied physiology · 2015Article
- Sex- and limb-specific differences in the nitric oxide-dependent cutaneous vasodilation in response to local heating.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Blunted cerebral blood flow velocity in response to a nitric oxide donor in postural tachycardia syndrome.American journal of physiology. Heart and circulatory physiology · 2014Article
- Postural orthostatic tachycardia syndrome: a dermatologic perspective and successful treatment with losartan.The Journal of clinical and aesthetic dermatology · 2014Article
- Postural tachycardia syndrome (POTS).Circulation · 2013Review
- Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Ascorbate improves circulation in postural tachycardia syndrome.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Low flow postural tachycardia syndrome (POTS), is associated with reduced nitric oxide (NO) activity assumed to be of endothelial origin. We tested the hypothesis that cutaneous microvascular neuronal NO (nNO) is impaired, rather than endothelial NO (eNO), in POTS. We performed three sets of experiments on subjects aged 22.5 +/- 2 yr. We used laser-Doppler flowmetry response to sequentially increase acetylcholine (ACh) doses and the local cutaneous heating response of the calf as bioassays for NO. During local heating we showed that when the selective neuronal nNO synthase (nNOS) inhibitor N(omega)-nitro-L-arginine-2,4-L-diaminobutyric amide (N(omega), 10 mM) was delivered by intradermal microdialysis, cutaneous vascular conductance (CVC) decreased by an amount equivalent to the largest reduction produced by the nonselective NO synthase (NOS) inhibitor nitro-L-arginine (NLA, 10 mM). We demonstrated that the response to ACh was minimally attenuated by nNOS blockade using N(omega) but markedly attenuated by NLA, indicating that eNO largely comprises the receptor-mediated NO release by ACh. We further demonstrated that the ACh dose response was minimally reduced, whereas local heat-mediated NO-dependent responses were markedly reduced in POTS compared with control subjects. This is consistent with intact endothelial function and reduced NO of neuronal origin in POTS. The local heating response was highly attenuated in POTS [60 +/- 6 percent maximum CVC(%CVC(max))] compared with control (90 +/- 4 %CVC(max)), but the plateau response decreased to the same level with nNOS inhibition (50 +/- 3 %CVC(max) in POTS compared with 47 +/- 2 %CVC(max)), indicating reduced nNO bioavailability in POTS patients. The data suggest that nNO activity but not NO of endothelial NOS origin is reduced in low-flow POTS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.