ArticleBiophysical journal2007
Domain formation in model membranes studied by pulsed-field gradient-NMR: the role of lipid polyunsaturation.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 78 citations in OpenAlex.
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- Phase Behavior of Binary Mixtures of SOPC and Cholesterol.ACS omega · 2025Review
- Understanding the coarse-grained free energy landscape of phospholipids and their phase separation.Biophysical journal · 2025Article
- Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function.Cold Spring Harbor perspectives in biology · 2023Review
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- Mechanistic insights into nanoparticle surface-bacterial membrane interactions in overcoming antibiotic resistance.Frontiers in microbiology · 2023Review
- Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness.Nature communications · 2020Article
- Lipid Membranes as Key Targets for the Pharmacological Actions of Ginsenosides.Frontiers in pharmacology · 2020Review
- Interaction mechanism between the focused ultrasound and lipid membrane at the molecular level.The Journal of chemical physics · 2019Article
- Molecular dynamics exploration of poration and leaking caused by Kalata B1 in HIV-infected cell membrane compared to host and HIV membranes.Scientific reports · 2017Article
- Phase Composition Control in Microsphere-Supported Biomembrane Systems.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation.The journal of physical chemistry. B · 2016Article
- The Affinity of Cholesterol for Different Phospholipids Affects Lateral Segregation in Bilayers.Biophysical journal · 2016Article
- Article
- HIV-1 antibodies and vaccine antigen selectively interact with lipid domains.Biochimica et biophysica acta · 2014Article
- Self-consistent mean-field model for palmitoyloleoylphosphatidylcholine-palmitoyl sphingomyelin-cholesterol lipid bilayers.Physical review. E, Statistical, nonlinear, and soft matter physics · 2011Article
- Lateral organization of complex lipid mixtures from multiscale modeling.The Journal of chemical physics · 2010Article
- Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small angle x-ray scattering, and molecular theory.Biophysical journal · 2009Article
- Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures.Biochimica et biophysica acta · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of increased unsaturation in the sn-2 fatty acyl chain of phosphatidylcholines (PCs) on the lipid lateral diffusion have been investigated by pulsed-field gradient NMR. Macroscopically oriented bilayers containing a monosaturated PC, egg sphingomyelin, and cholesterol (CHOL) have been studied at temperatures between 0 degrees C and 60 degrees C, and the number of double bonds in the PC was one, two, four, or six. For PC bilayers, with and without the incorporation of egg sphingomyelin and CHOL, the lateral diffusion increased with increasing number of double bonds, as a consequence of the increased headgroup area caused by the unsaturation. Addition of CHOL caused a decrease in lipid diffusion due to the condensing effect of CHOL on the headgroup area. Phase separation into large domains of liquid-disordered and liquid-ordered phases were observed in the ternary systems with PCs containing four and six double bonds, as evidenced by the occurrence of two lipid diffusion coefficients. PC bilayers with one or two double bonds appear homogeneous on the length scales probed by the experiment, but the temperature dependence of the diffusion suggests that small domains may be present also in these ternary systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.