ArticleBiophysical journal2007
Quantitative evaluation of sensitivity and selectivity of multiplex nanoSPR biosensor assays.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Nanomaterial-Enhanced Biosensing: Mechanisms and Emerging Applications.Advanced healthcare materials · 2025Review
- Multiplex NanoSPR Molecular Biosensor for Blood Cytokine Monitoring.Advanced pharmaceutical bulletin · 2022Article
- Surface Plasmon Resonance Assay for Label-Free and Selective Detection of HIV-1 p24 Protein.Biosensors · 2021Article
- Nanosensors based on LSPR are able to serologically differentiate dengue from Zika infections.Scientific reports · 2020Article
- Facile phase transfer of gold nanorods and nanospheres stabilized with block copolymers.Beilstein journal of nanotechnology · 2018Article
- A Sensitive and Stable Surface Plasmon Resonance Sensor Based on Monolayer Protected Silver Film.Sensors (Basel, Switzerland) · 2017Article
- Nanophotonic detection of freely interacting molecules on a single influenza virus.Scientific reports · 2015Article
- Localized Surface Plasmon Resonance Biosensing: Current Challenges and Approaches.Sensors (Basel, Switzerland) · 2015Review
- Replacement of cetyltrimethylammoniumbromide bilayer on gold nanorod by alkanethiol crosslinker for enhanced plasmon resonance sensitivity.Biosensors & bioelectronics · 2013Article
- Chemisorption assembly of Au nanorods on mercaptosilanized glass substrate for label-free nanoplasmon biochip.Analytica chimica acta · 2013Article
- Quantitative LSPR imaging for biosensing with single nanostructure resolution.Biophysical journal · 2013Article
- Anisotropic nanomaterials: structure, growth, assembly, and functions.Nano reviews · 2011Article
- A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands.ACS nano · 2010Article
- Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells.Nano letters · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new functionalization procedure was developed to replace cyltrimethylammoniumbromide coating on gold nanorods (GNRs) fabricated through seed-mediated growth with chemically active alkanethiols; antibodies were then attached to the GNRs to yield gold nanorod molecular probes (GNrMPs). The functionalization procedure was shown to minimize nonspecific binding. Multiplex sensing was demonstrated for three targets (goat anti-human IgG, goat anti-rabbit IgG, and goat anti-mouse IgG) through the distinct response of the plasmon spectra of GNrMPs to binding events. Quantification of the plasmonic binding events and estimation of ligand binding kinetics tethered to these nanoscale structures was also demonstrated through a mathematical approach. Evaluation of the experimental and theoretical data yields an affinity constant K(a) = 1.34 x 10(7) M(-1), which was in agreement with the IgG-antiIgG binding affinity reported in the literature. The GNrMP sensors were found to be highly specific and sensitive with the dynamic response in the range between 10(-9) M and 10(-6) M. The limit of detection of GNrMPs was found to be in the low nanomolar range, and is a function of the binding affinity: for a higher probe-target affinity pair, the limit of detection can be expected to reach femto molar levels. This technique can play a key role in developing tunable sensors for sensitive and precise monitoring of biological interactions.
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