ArticleReproduction (Cambridge, England)2007
Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition.
Article in Reproduction (Cambridge, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 197 citations in OpenAlex.
- Molecular mechanisms and multi-organ regulatory roles of anti-Müllerian hormone in female reproduction.Communications biology · 2026Review
- AMH regulates ovary size by counteracting the positive influence of clustered ovarian follicle growth.Human reproduction (Oxford, England) · 2026Article
- Review
- The importance of ovary-immune interactions in the context of age and disease.Frontiers in neuroendocrinology · 2026Review
- The Effect of AMH on Folliculogenesis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Trigonelline activates NRF2 and awakens dormant ovarian follicles to promote pregnancy in aging mice.iScience · 2025Article
- The elusive function of AMH signaling in folliculogenesis.Journal of assisted reproduction and genetics · 2025Article
- Predictive value of AMH in late reproductive age: a retrospective cohort study.Scientific reports · 2025Article
- Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics†.Biology of reproduction · 2025Article
- Effect of circulating anti-Mullerian hormone on the reproductive potential of gilts.Frontiers in veterinary science · 2025Article
- Loss of ERβ Disrupts Gene Regulation in Primordial and Primary Follicles.International journal of molecular sciences · 2024Article
- Anti-Mullerian hormone attenuates both cyclophosphamide-induced damage and PI3K signalling activation, while rapamycin attenuates only PI3K signalling activation, in human ovarian cortex in vitro.Human reproduction (Oxford, England) · 2024Article
- Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment.Frontiers in cell and developmental biology · 2024Article
- The roles of anti-Müllerian hormone in breast cancer.Endocrine-related cancer · 2023Review
- Making a good egg: human oocyte health, aging, and in vitro development.Physiological reviews · 2023Review
- Anti-Müllerian hormone-mediated preantral follicle atresia is a key determinant of antral follicle count in mice.Human reproduction (Oxford, England) · 2022Article
- Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle.BMC pregnancy and childbirth · 2022Article
- Therapeutic options for premature ovarian insufficiency: an updated review.Reproductive biology and endocrinology : RB&E · 2022Review
- Cyclin-dependent kinase 6 (CDK6) as a potent regulator of the ovarian primordial-to-primary follicle transition.Frontiers in cell and developmental biology · 2022Article
- Ovarian Reserve Biomarkers and Menstrual Cycle Length in a Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2021Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The oocytes found within the primordial follicles of mammalian ovaries remain quiescent for months to years until they receive the appropriate signals to undergo the primordial to primary follicle transition and initiate folliculogenesis. The molecular mechanisms and extracellular signaling factors that regulate this process remain to be fully elucidated. The current study investigates the mechanisms utilized by anti-Müllerian hormone (AMH; i.e. Müllerian inhibitory substance) to inhibit the primordial to primary follicle transition. Ovaries from 4-day-old rats were placed into organ culture and incubated in the absence or presence of AMH, either alone or in combination with known stimulators of follicle transition, including basic fibroblast growth factor (bFGF), kit ligand (KITL), or keratinocyte growth factor (KGF). Following 10 days of culture, the ovaries were sectioned, stained, and morphologically evaluated to determine the percentage of primordial versus developing follicles. As previously demonstrated, AMH treatment decreased primordial to primary follicle transition. Interestingly, AMH inhibited the stimulatory actions of KITL, bFGF, and KGF. Therefore, AMH can inhibit the basal and stimulated development of primordial follicles. To investigate the mechanism of AMH actions, the influence AMH has on the ovarian transcriptome was analyzed. AMH treatment when compared with controls was found to alter the expression of 707 genes. The overall effect of AMH exposure is to decrease the expression of stimulatory factors, increase the expression of inhibitory factors, and regulate cellular pathways (e.g. transforming growth factor beta signaling pathway) that result in the inhibition of primordial follicle development. Analysis of the regulatory factors and cellular pathways altered by AMH provides a better understanding of the molecular control of primordial follicle development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.