ArticleLung cancer (Amsterdam, Netherlands)2007
DNA methylation profile of 28 potential marker loci in malignant mesothelioma.
Article in Lung cancer (Amsterdam, Netherlands), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations.Scientific reports · 2021Article
- Molecular Fingerprints of Malignant Pleural Mesothelioma: Not Just a Matter of Genetic Alterations.Journal of clinical medicine · 2021Review
- The Molecular Basis of Malignant Pleural Mesothelioma.Thoracic surgery clinics · 2020Review
- Expression of estrogen receptor beta (ERβ) and its prognostic value in pleural mesothelioma.Journal of thoracic disease · 2019Article
- Article
- Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2017Article
- Article
- Hypomethylation reduced the aggressive potential of human malignant mesothelioma cells.Cancer gene therapy · 2016Article
- Reduction of estradiol in human malignant pleural mesothelioma tissues may prevent tumour growth, as implied by in in-vivo and in-vitro models.Oncotarget · 2016Article
- Methylation of multiple genes in hepatitis C virus associated hepatocellular carcinoma.Journal of advanced research · 2014Article
- Article
- Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer.Translational oncology · 2013Article
- Expression of metallothionein and Nrf2 pathway genes in lung cancer and cancer-surrounding tissues.World journal of surgical oncology · 2013Article
- Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.Cancer science · 2012Article
- Article
- Epigenomics in environmental health.Frontiers in genetics · 2011Article
- Biomarkers for early detection of malignant mesothelioma: diagnostic and therapeutic application.Cancers · 2010Article
- hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma.Cancer research · 2010Article
- Article
- Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis.Breast cancer research and treatment · 2009Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with malignant mesothelioma (MM), an aggressive cancer associated with asbestos exposure, usually present clinically with advanced disease and this greatly reduces the likelihood of curative treatment. MM is difficult to diagnose without invasive techniques; the development of non-invasively detectable molecular markers would therefore be highly beneficial. DNA methylation changes in cancer cells provide powerful markers that are potentially detectable non-invasively in DNA shed into bodily fluids. Here we examined the methylation status of 28 loci in 52 MM tumors to investigate their potential as molecular markers for MM. To exclude candidate MM markers that might be positive in biopsies/pleural fluid due to contaminating surrounding non-tumor lung tissue/DNA, we also examined the methylation of these markers in lung samples (age- or environmentally induced hypermethylation is frequently observed in non-cancerous lung). Statistically significantly increased methylation in MM versus non-tumor lung samples was found for estrogen receptor 1 (ESR1; p = 0.0002), solute carrier family 6 member 20 (SLC6A20; p = 0.0022) and spleen tyrosine kinase (SYK; p=0.0003). Examination of associations between methylation levels of the 28 loci and clinical parameters suggest associations of the methylation status of metallothionein genes with gender, histology, asbestos exposure, and lymph node involvement, and the methylation status of leucine zipper tumor suppressor 1 (LZTS1) and SLC6A20 with survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.