ReviewAdvanced drug delivery reviews2007
Delivery of drugs and macromolecules to mitochondria.
Review in Advanced drug delivery reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Ontogeny of drug-induced fatty liver disease (DIFLD): from key initiating events to disease phenotypes.Archives of toxicology · 2025Review
- A Systematic Review of Carotenoids in the Management of Age-Related Macular Degeneration.Antioxidants (Basel, Switzerland) · 2021Review
- Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- The noncoding-RNA landscape in cardiovascular health and disease.Non-coding RNA research · 2018Review
- A Triphenylphosphonium-Functionalized Mitochondriotropic Nanocarrier for Efficient Co-Delivery of Doxorubicin and Chloroquine and Enhanced Antineoplastic Activity.Pharmaceuticals (Basel, Switzerland) · 2017Article
- Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags.Journal of the American Chemical Society · 2017Article
- Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance.Journal of the American Chemical Society · 2016Article
- Nanoparticle Uptake: The Phagocyte Problem.Nano today · 2015Article
- Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.Nature communications · 2015Article
- Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action.PloS one · 2015Article
- Mitochondrial delivery of doxorubicin by triphenylphosphonium-functionalized hyperbranched nanocarriers results in rapid and severe cytotoxicity.Pharmaceutical research · 2013Article
- Alkyne-azide "click" chemistry in designing nanocarriers for applications in biology.Molecules (Basel, Switzerland) · 2013Review
- Toward intracellular targeted delivery of cancer therapeutics: progress and clinical outlook for brain tumor therapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2012Article
- Mitochondrial dysfunction in retinal diseases.Current eye research · 2011Review
- Multiple triphenylphosphonium cations as a platform for the delivery of a pro-apoptotic peptide.Pharmaceutical research · 2011Article
- Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- Receptor-targeted nanocarriers for therapeutic delivery to cancer.Molecular membrane biology · 2010Review
- Strategies in the design of nanoparticles for therapeutic applications.Nature reviews. Drug discovery · 2010Review
- Controlling subcellular delivery to optimize therapeutic effect.Therapeutic delivery · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mitochondria is where the bulk of the cell's ATP is produced. Mutations occur to genes coding for members of the complexes involved in energy production. Some are a result of damages to nuclear coded genes and others to mitochondrial coded genes. This review describes approaches to bring small molecules, proteins and RNA/DNA into mitochondria. The purpose is to repair damaged genes as well as to interrupt mitochondrial function including energy production, oxygen radical formation and the apoptotic pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.