ArticleWorld journal of gastroenterology2007
COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Vascular plasticity in the gastric cancer environment: mechanisms, prognostic significance, and concepts of therapeutic interventions.Cancer metastasis reviews · 2026Review
- Assessing the Malignant Potential of Gastric Mucosa Disorders: A Pilot Study on Lipid Peroxidation End Products and COX-2 Detection by Immunohistochemistry.Molecular carcinogenesis · 2026Article
- Gastric carcinogenesis: a comprehensive review of the angiogenic pathways.Clinical journal of gastroenterology · 2021Review
- The clinical significance of Notch1 immunoexpression in Caucasian patients with colorectal adenocarcinoma.Przeglad gastroenterologiczny · 2020Article
- Ethanol extracts ofFood & nutrition research · 2019Article
- Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice.Frontiers in immunology · 2015Article
- Role of cyclooxygenase-2 in gastric cancer development and progression.World journal of gastroenterology · 2013Review
- Role of Notch signaling pathway in gastric cancer pathogenesis.Contemporary oncology (Poznan, Poland) · 2013Article
- COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: a quantitative immunohistochemical analysis of RTOG C0128.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2013Article
- Prognostic significance of cyclooxygenase-2, epidermal growth factor receptor 1, and microvascular density in gastric cancer.Medical oncology (Northwood, London, England) · 2012Article
- Article
- Study on the association of COX-2 genetic polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu province in China.Molecular biology reports · 2011Article
- Expression of COX-2 in stomach carcinogenesis.Journal of gastrointestinal cancer · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the expression and clinicopathological significance of cyclooxygenase-2 (COX-2) and microvessel density (MVD) in gastric carcinogenesis, and to investigate their roles in the invasion and the relationship between biological behaviors and prognosis of gastric cancer.
methodsUsing Envision immunohistochemistry, COX-2 and CD34 expressions in gastric cancer tissue array were examined. MVD was counted and the relationship between the biological behaviors and prognosis was analyzed.
resultsThe expression of COX-2 in gastric cancer tissue was significantly higher than that in normal mucosa (c2 = 12.191, P < 0.05). The over-expression of COX-2 in gastric cancer was obviously related to metastasis and depth of invasion (c2 = 6.315, P < 0.05), but not related to the histological type and Borrmann type (c2 = 5.391 and c2 = 2.228, respectively). Moreover, MVD in gastric cancer tissues was significantly higher than that in the normal mucosa (65.49 +/- 20.64 vs 36.21 +/- 18.47, t/F = 7.53, P < 0. 05). MVD was related to the histologic type and metastasis (t/F = 3.68 and t/F = 4.214, respectively, P < 0. 05), but not related to the depth of invasion and Borrmann type (t/F = 0.583 and t/F = 0.459, respectively). MVD in COX-2-positive tissues was markedly higher compared to COX-2-negative tissues, indicating a positive correlation between COX-2 expression and MVD (t = 13.12, P < 0. 05).
conclusionTissue microarray (TMA) is a powerful tool for rapid identification of the molecular alterations in gastric cancer. COX-2 expression, via inducing angiogenesis, may play an important role in gastric carcinogenesis. It could be served as a determinant factor for clinical prognosis and curative effect.
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