ArticleLasers in surgery and medicine2007
Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time.
Article in Lasers in surgery and medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Photobiomodulation of gingival lesions resulting from autoimmune diseases: systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Does low level laser therapy has effects on inflammatory biomarkers IL-1β, IL-6, TNF-α, and MMP-13 in osteoarthritis of rat models-a systemic review and meta-analysis.Lasers in medical science · 2021Pooled it
- Review of light parameters and photobiomodulation efficacy: dive into complexity.Journal of biomedical optics · 2018Pooled it
- The effect of low-level laser therapy on knee osteoarthritis: prospective, descriptive study.Lasers in medical science · 2014Trial
- The effect of 810-nm low-level laser therapy on pain caused by orthodontic elastomeric separators.Lasers in medical science · 2014Trial
- The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial.Photomedicine and laser surgery · 2009Trial
- Amelioration of Alzheimer's Disease Pathology in Zebrafish by Photobiomodulation.Biomedicines · 2025Article
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- Use ofAging cell · 2023Article
- The Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Twenty cases of perennial and seasonal allergic rhinitis treated with LumiMed® Nasal Device.Journal of medical case reports · 2023Article
- Effects of low-level laser therapy and therapeutic ultrasound on Freund's complete adjuvant-induced knee arthritis model in rats.Archives of rheumatology · 2023Article
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- Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells.Scientific reports · 2021Article
- Laser treatment of synovial inflammatory process in experimentally induced microcrystalline arthritis in Wistar rats.Lasers in medical science · 2021Article
- Molecular and Cellular Mechanisms of Arthritis in Children and Adults: New Perspectives on Applied Photobiomodulation.International journal of molecular sciences · 2020Review
- Photobiostimulation activity of different low-level laser dosage on masticatory muscles and temporomandibular joint in an induced arthritis rat model.Lasers in medical science · 2020Article
- Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model.Lasers in medical science · 2019Article
- Synergistic effects of vacuum therapy and laser therapy on physical rehabilitation.Journal of physical therapy science · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIt has been proposed for many years that low-level laser (or light) therapy (LLLT) can ameliorate the pain, swelling, and inflammation associated with various forms of arthritis. Light is thought to be absorbed by mitochondrial chromophores leading to an increase in adenosine triphosphate (ATP), reactive oxygen species and/or cyclic AMP production and consequent gene transcription via activation of transcription factors. However, despite many reports about the positive effects of LLLT in arthritis and in medicine in general, its use remains controversial. For all indications (including arthritis) the optimum optical parameters have been difficult to establish and so far are unknown.
methodsWe tested LLLT on rats that had zymosan injected into their knee joints to induce inflammatory arthritis. We compared illumination regimens consisting of a high and low fluence (3 and 30 J/cm(2)), delivered at high and low irradiance (5 and 50 mW/cm(2)) using 810-nm laser light daily for 5 days, with the positive control of conventional corticosteroid (dexamethasone) therapy.
resultsIllumination with 810-nm laser was highly effective (almost as good as dexamethasone) at reducing swelling and a longer illumination time (10 or 100 minutes compared to 1 minute) was more important in determining effectiveness than either the total fluence delivered or the irradiance. LLLT induced reduction of joint swelling correlated with reduction in the inflammatory marker serum prostaglandin E2 (PGE2).
conclusionLLLT with 810-nm laser is highly effective in treating inflammatory arthritis in this model. Longer illumination times were more effective than short times regardless of total fluence or irradiance. These data will be of value in designing clinical trials of LLLT for various arthritides.
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