ReviewHuman genetics2007
Progress in defining the molecular biology of age related macular degeneration.
Review in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Can genetic risk information for age-related macular degeneration influence motivation to stop smoking? A pilot study.Eye (London, England) · 2012Trial
- Single-cell RNA Sequencing Identifies Natural Kill Cell-Related Transcription Factors Associated With Age-Related Macular Degeneration.Evolutionary bioinformatics online · 2024Article
- Metabolomics and Age-Related Macular Degeneration.Metabolites · 2018Review
- The complexities underlying age-related macular degeneration: could amyloid beta play an important role?Neural regeneration research · 2017Review
- Dementia of the eye: the role of amyloid beta in retinal degeneration.Eye (London, England) · 2015Review
- Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress.Cellular and molecular neurobiology · 2015Article
- Evaluation of cardiovascular biomarkers in patients with age-related wet macular degeneration.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
- Bowman lecture on the role of inflammation in degenerative disease of the eye.Eye (London, England) · 2013Article
- Age-related retinopathy in NRF2-deficient mice.PloS one · 2011Article
- Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.Archives of toxicology · 2010Review
- Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival.The Journal of biological chemistry · 2010Article
- Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.Molecular vision · 2010Article
- Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women.Journal of bone and mineral metabolism · 2010Article
- The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.Progress in retinal and eye research · 2010Review
- Genetic basis of inherited macular dystrophies and implications for stem cell therapy.Stem cells (Dayton, Ohio) · 2009Review
- Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration.Experimental eye research · 2009Article
- Retinal pigment epithelium culture;a potential source of retinal stem cells.Journal of ophthalmic & vision research · 2009Article
- Biologically active fibronectin fragments stimulate release of MCP-1 and catabolic cytokines from murine retinal pigment epithelium.Investigative ophthalmology & visual science · 2009Article
- Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors.Journal of molecular medicine (Berlin, Germany) · 2009Review
- Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.BMC medical genomics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Age related macular degeneration (AMD) is an extremely prevalent complex genetic disorder. Its incidence rises exponentially in the elderly to a frequency of 1 in 2 in the general population by age 85. It affects approximately 25 million people and is the commonest cause of irreversible visual loss in the Western world. It is therefore a major public health problem. However, until recently its aetiology was unknown. Our understanding of both the molecular biology of AMD and the relevant clinical treatments has progressed dramatically in the last 2 years. Two genes of large effect have been identified which together contribute to over 70% of the population attributable risk of AMD. Treatments which inhibit expression of vascular endothelial growth factor have been developed which can rescue vision in the "wet" form of the disease. The association of complement factor H with AMD highlights the importance of the alternative complement pathway in the development of AMD whilst the pathophysiology of the serine protease HTRA1 is now under intensive study. This review will give an insight into these developments and will summarise our current knowledge of the molecular biology of AMD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.