ArticleFEBS letters2007
Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis.
Article in FEBS letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk.Gastroenterology · 2008Trial
- Characteristics of amino acid metabolism in colorectal cancer.World journal of clinical cases · 2023Review
- Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles.Scientific reports · 2017Article
- Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis.Oncotarget · 2017Article
- Increased transforming growth factor β and interleukin 10 transcripts in peripheral blood mononuclear cells of colorectal cancer patients.Contemporary oncology (Poznan, Poland) · 2016Article
- Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis.Theranostics · 2015Article
- Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification.Journal of Cancer · 2013Article
- Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis.Cancer letters · 2011Article
- Light-scattering technologies for field carcinogenesis detection: a modality for endoscopic prescreening.Gastroenterology · 2011Article
- Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Measuring mucosal blood supply in vivo with a polarization-gating probe.Applied optics · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of EIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon-specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between EIBS and iNOS expression/activity. Importantly, we also observed that short-term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.