ArticleExperimental neurology2007
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.
Article in Experimental neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study.Pain medicine (Malden, Mass.)Trial
- Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders.Cells · 2022Review
- Reduced Acquisition Time [Frontiers in medicine · 2022Article
- Unravelling neuroinflammation in abusive head trauma with radiotracer imaging.Pediatric radiology · 2021Review
- Recent developments on PET radiotracers for TSPO and their applications in neuroimaging.Acta pharmaceutica Sinica. B · 2021Review
- Positron Emission Tomography Techniques to Measure Active Inflammation, Fibrosis and Angiogenesis: Potential for Non-invasive Imaging of Hypertensive Heart Failure.Frontiers in cardiovascular medicine · 2021Review
- Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series.Neurobiology of disease · 2020Article
- Microglia Receptors in Animal Models of Traumatic Brain Injury.Molecular neurobiology · 2019Review
- PET Evaluation of Microglial Activation in Non-neurodegenerative Brain Diseases.Current neurology and neuroscience reports · 2019Review
- TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward.Pharmacology & therapeutics · 2019Review
- Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study.Journal of neuroinflammation · 2018Article
- Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Microglial Activation in Traumatic Brain Injury.Frontiers in aging neuroscience · 2017Review
- Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice.Journal of neuroinflammation · 2016Article
- Changes in Binding of [(123)I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury.Neuromolecular medicine · 2016Article
- Mapping the Connectome Following Traumatic Brain Injury.Current neurology and neuroscience reports · 2016Review
- Injury-Dependent and Disability-Specific Lumbar Spinal Gene Regulation following Sciatic Nerve Injury in the Rat.PloS one · 2015Article
- Imaging Neuroinflammation - from Bench to Bedside.Journal of clinical & cellular immunology · 2014Article
- The neuroinflammatory response in humans after traumatic brain injury.Neuropathology and applied neurobiology · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) is a significant cause of mortality, morbidity, and disability. Microglial activation is commonly observed in response to neuronal injury which, when prolonged, is thought to be detrimental to neuronal survival. Activated microglia can be labeled using PK11195, a ligand that binds the peripheral benzodiazepine receptor (PBR), receptors which are increased in activated microglia and sparse in the resting brain. We compared the binding properties of two PBR ligands PK11195 and DAA1106 in rats using the controlled cortical impact (CCI) model of experimental TBI. While both ligands showed relative increases with specific binding in the cortex ipsilateral to injury compared to the contralateral side, [(3)H]DAA1106 showed higher binding affinity compared with [(3)H](R)-PK11195. Combined immunohistochemistry and autoradiography in brain tissues near the injury site showed that [(3)H]DAA1106 binding co-registered with activated microglia more than astrocytes. Further, increased [(3)H]DAA1106-specific binding positively correlated with the degree of microglial activation, and to a lesser degree with reactive astrocytosis. Finally, in vivo administration of each ligand in rats with TBI showed greater retention of [(11)C]DAA1106 compared to [(11)C](R)-PK11195 at the site of the contusion as assessed by ex vivo autoradiography. These results in a rat model of TBI indicate that [(11)C]DAA1106 binds with higher affinity to microglia when compared with PK11195, suggesting that [(11)C]DAA1106 may represent a better ligand than [(11)C](R)-PK11195 for in vivo PET imaging of activated microglia in TBI.
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