ArticleBrain research2007
Effect of the alpha subunit subtype on the macroscopic kinetic properties of recombinant GABA(A) receptors.
Article in Brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 60 citations in OpenAlex.
- Molecular assemblies and pharmacology of cerebellar GABAProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Region and layer-specific expression of GABAFrontiers in cellular neuroscience · 2024Article
- Shisa7-Dependent Regulation of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats.Neurochemical research · 2021Article
- Electrophysiology of ionotropic GABA receptors.Cellular and molecular life sciences : CMLS · 2021Review
- Relocation of an Extrasynaptic GABANeuron · 2021Article
- Article
- Regulation of GABAInternational journal of molecular sciences · 2020Review
- Comparison of biophysical properties of α1β2 and α3β2 GABAA receptors in whole-cell patch-clamp electrophysiological recordings.PloS one · 2020Article
- GABAPsychopharmacology · 2018Review
- Examining the effects of alcohol on GABAAlcohol (Fayetteville, N.Y.) · 2018Article
- Crystal structures of a GABANature structural & molecular biology · 2017Article
- Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus.Nature communications · 2017Article
- Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABAACS chemical neuroscience · 2017Article
- During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons.Neuropharmacology · 2016Article
- A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition.Neuron · 2015Article
- Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons.Neuron · 2015Article
- The developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy.Neurobiology of disease · 2015Article
- Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors.Neuropharmacology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The GABA(A) receptors (GABARs) are chloride-permeable ligand-gated ion channels responsible for fast inhibitory neurotransmission. These receptors are structurally heterogeneous, and in mammals can be formed from a combination of sixteen different subunit subtypes. Much of this variety comes from the six different alpha subunit subtypes. All neuronal GABARs contain an alpha subunit, and the identity of the alpha subtype affects the pharmacological properties of the receptors. The expression of each of the different alpha subtypes is regulated developmentally and regionally and changes with both normal physiological processes such development and synaptic plasticity, and pathological conditions such as epilepsy. In order to understand the functional significance of this structural heterogeneity, we examined the effect of the alpha subtype on the receptor's response to GABA. Each of the six alpha subtypes was transiently co-expressed with the beta3 and gamma2L subunits in mammalian cells. The sensitivity to GABA was measured with whole-cell recordings. We also determined the activation, deactivation, desensitization, and recovery kinetics for the six isoforms using rapid application recordings from excised macropatches. We found unique characteristics associated with each alpha subunit subtype. These properties would be expected to influence the post-synaptic response to GABA, creating functional diversity among neurons expressing different alpha subunits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.