ArticleBiochemical and biophysical research communications2007
Genistein induces the metastasis suppressor kangai-1 which mediates its anti-invasive effects in TRAMP cancer cells.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens.Biomedicines · 2024Review
- The role of isoflavones in augmenting the effects of radiotherapy.Frontiers in oncology · 2022Review
- Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets.Cells · 2020Review
- Chemoprevention in gastrointestinal physiology and disease. Targeting the progression of cancer with natural products: a focus on gastrointestinal cancer.American journal of physiology. Gastrointestinal and liver physiology · 2016Review
- The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets.Oncotarget · 2015Review
- PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion.Oncotarget · 2015Article
- Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.Clinical & experimental metastasis · 2014Article
- Genistein inhibits human prostate cancer cell detachment, invasion, and metastasis.The American journal of clinical nutrition · 2014Review
- Development of anticancer drugs based on the hallmarks of tumor cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer.The Journal of biological chemistry · 2011Article
- Inhibition of cancer cell invasion and metastasis by genistein.Cancer metastasis reviews · 2010Review
- Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis.Cancer research · 2009Article
- Learning therapeutic lessons from metastasis suppressor proteins.Nature reviews. Cancer · 2009Review
- Influence of diet on metastasis and tumor dormancy.Clinical & experimental metastasis · 2009Review
- Multi-targeted therapy of cancer by genistein.Cancer letters · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies demonstrated a direct correlation with loss of kangai-1 (KAI1), a metastasis suppressor, and poor prognosis in human prostate and other cancers. In this study, we have characterized the age-dependent downregulation of KAI1 in the TRAMP model which was reversed when mice were fed a genistein-enriched diet. We demonstrated here that doses of genistein (5 and 10 microM)--achievable by supplement intake--significantly induced the expression of KAI1, both at the mRNA and protein levels (up to 2.5-fold), and decreased the invasiveness of TRAMP-C2 cells >2.0-fold. We have pinpointed KAI1 as the invasion suppressor, since its knockdown by siRNA restored the invasive potential of genistein-treated TRAMP-C2 cells to control levels. This work provides the first evidence that genistein treatment may counteract KAI1 downregulation, which is observed in many cancer types and therefore, could be used in anti-metastatic therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.